Piroctone olamine
Description Appearance Solubility Toxicity- Product Name
- Piroctone olamine
- CAS No.
- 68890-66-4
- Chemical Name
- Piroctone olamine
- Synonyms
- OCTOPIROX;OCTO;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one;PIROCTONE OLEAMINE;LGB-PO;octopiroxolamine;PIROCTONE OLAMINE;Piorctone Olamine;PiroCLone olaMine;Pirotone Oleamine
- CBNumber
- CB6433396
- Molecular Formula
- C16H30N2O3
- Formula Weight
- 298.43
- MOL File
- 68890-66-4.mol
Piroctone olamine Property
- Melting point:
- 134.0 to 138.0 °C
- Boiling point:
- 135-235℃[at 101 325 Pa]
- Density
- 1.1[at 20℃]
- vapor pressure
- 0-0Pa at 20-25℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly, Sonicated), Methanol (Slightly)
- pka
- 5.9-7.4[at 20 ℃]
- color
- White to Off-White
- Water Solubility
- 400-50000mg/L at 20-25℃
- Merck
- 14,7502
- InChI
- InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
- InChIKey
- BTSZTGGZJQFALU-UHFFFAOYSA-N
- SMILES
- C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
- LogP
- 1.05-3.86 at 20-25℃
- CAS DataBase Reference
- 68890-66-4(CAS DataBase Reference)
Safety
- WGK Germany
- 2
- RTECS
- UU7786150
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 51872
- Product name
- Piroctone olamine
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 1544406
- Product name
- Piroctone olamine
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- P2178
- Product name
- Piroctone Olamine
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $141
- Updated
- 2024/03/01
- Product number
- P2178
- Product name
- Piroctone Olamine
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $471
- Updated
- 2024/03/01
- Product number
- PHR2187
- Product name
- Piroctone Olamine
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $689
- Updated
- 2024/03/01
Piroctone olamine Chemical Properties,Usage,Production
Description
Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Appearance
White or slightly yellow crystalline powder.
Solubility
Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.
Toxicity
Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.
Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).
Chronic toxicity and carcinogencity : Negative.
Mutagenicity : Negative.
Irritation to skin and eye : Very low.
Uses
Piroctone Olamine is an anti-dandruff agent used in shampoo formulations.
Uses
Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.
Definition
ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone.
brand name
Octopirox (Hoechst AG, Germany).
Mechanism of action
Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions. It works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism. Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death. It also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.
Side effects
It should be kept in mind that shampoos with Piroctone Olamine should not be used more than twice a week, unlike other daily-use shampoos that don't have this ingredient. One of the biggest side effects of Piroctone Olamine is that it can cause irritation and itchiness on the head.
Piroctone olamine Preparation Products And Raw materials
Raw materials
Preparation Products
Piroctone olamine Suppliers
View Lastest Price from Piroctone olamine manufacturers
- Product
- Piroctone Olamine 68890-66-4
- Price
- US $85.00/Kg/Drum
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 20 tons/month
- Release date
- 2020-06-24
- Product
- Piroctone olamine 68890-66-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000 TONS
- Release date
- 2024-03-25
- Product
- Piroctone olamine 68890-66-4
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200mt/year
- Release date
- 2022-01-26