Piroctone olamine

Description Appearance Solubility Toxicity

Product Name: Piroctone olamine
CAS No.: 68890-66-4
Chemical Name: Piroctone olamine
Synonyms: OCTOPIROX;OCTO;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one;PIROCTONE OLEAMINE;LGB-PO;octopiroxolamine;HIC-cosmetics-RM;PIROCTONE OLAMINE;Piorctone Olamine;PiroCLone olaMine
CBNumber: CB6433396
Molecular Formula: C16H30N2O3
Formula Weight: 298.43
MOL File: 68890-66-4.mol

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Piroctone olamine Property

Melting point:: 134.0 to 138.0 °C
Boiling point:: 135-235℃[at 101 325 Pa]
Density: 1.1[at 20℃]
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka: 5.9-7.4[at 20 ℃]
form: Solid
color: White to Off-White
Water Solubility: 400-50000mg/L at 20-25℃
Merck: 14,7502
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey: BTSZTGGZJQFALU-UHFFFAOYSA-N
SMILES: C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
LogP: 1.05-3.86 at 20-25℃
CAS DataBase Reference: 68890-66-4(CAS DataBase Reference)

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Safety

WGK Germany: 2
RTECS: UU7786150
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 51872
Product name: Piroctone olamine
Purity: analytical standard
Packaging: 100mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1544406
Product name: Piroctone olamine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: P2178
Product name: Piroctone Olamine
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: P2178
Product name: Piroctone Olamine
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $471
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2187
Product name: Piroctone Olamine
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $689
Updated: 2024/03/01

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Piroctone olamine Chemical Properties,Usage,Production

Description

Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Appearance

White or slightly yellow crystalline powder.

Solubility

Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.

Toxicity

Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.

Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).

Chronic toxicity and carcinogencity : Negative.

Mutagenicity : Negative.

Irritation to skin and eye : Very low.

Uses

Piroctone Olamine is an anti-dandruff agent used in shampoo formulations.

Uses

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Definition

ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone.

brand name

Octopirox (Hoechst AG, Germany).

benefits

Piroctone Olamine is a popular ingredient in hair care products that treat dandruff and other scalp conditions. Controls dandruff: Piroctone Olamine is effective at controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues. By controlling the growth of this yeast, Piroctone Olamine can help to reduce or eliminate dandruff. Soothes the scalp: Piroctone Olamine has moisturizing properties that can help to soothe and hydrate the scalp. This can help prevent dryness, flakiness, and itching, common symptoms of dandruff and other scalp conditions. Safe for coloured hair: Piroctone Olamine is safe for use on coloured hair and will not cause fading or strip colour. Prevents fungal growth: Piroctone Olamine not only controls the growth of Malassezia, but it also prevents the growth of other fungi that can cause scalp problems. Long-lasting effect: Piroctone Olamine has been shown to have a longer-lasting effect than some other dandruff-fighting ingredients, meaning you may be able to go longer between washes. Gentle on the scalp: Piroctone Olamine is gentle on the scalp, making it suitable for sensitive skin.

Mechanism of action

Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions. It works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism. Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death. It also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.

Side effects

It should be kept in mind that shampoos with Piroctone Olamine should not be used more than twice a week, unlike other daily-use shampoos that don't have this ingredient. One of the biggest side effects of Piroctone Olamine is that it can cause irritation and itchiness on the head.

Piroctone olamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Piroctone olamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Piroctone olamine 68890-66-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥99%
Supply Ability: 1000kg/month
Release date: 2021-06-21

BLiT (Hefei)Chemical Co.,Ltd

Product: Piroctone olamine 68890-66-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000 TONS
Release date: 2024-03-25

Jinan Finer Chemical Co., Ltd

Product: Piroctone olamine 68890-66-4
Price: US $0.00/公斤
Min. Order: 1公斤
Purity: 99%
Supply Ability: 500mt/year
Release date: 2024-08-15

68890-66-4, Piroctone olamineRelated Search:

Ciclopirox ethanolamine Monoethanolamine Methylparaben Sodium Pyrithione Pyridine hydrochloride Kresoxim-methyl CHLOROPHOSPHONAZO III Zinc pyrithione 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Basic Violet 1 Methyl salicylate Tribenuron methyl Methanol Piroctone Oxybenzone Niclosamide ethanolamine salt Methyl acrylate DIETHANOLAMINE HYDROCHLORIDE

2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1)

4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon

octopiroxolamine

1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1)

Hydroxyl pyrazole ketones

1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)

-one compound with 2-aminoethanol (1:1)

Ethanolamine salt (1:1)

Piroctone olamine Solution, 100ppm

PIROCTONE OLAMINE 98.0+%

1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt

OCTOPIROX

PIROCTONE OLAMINE

Piroctone olamine (OCTO)

PIROCTONE OLEAMINE

1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

Piorctone Olamine

1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)2(1H)-PYRIDONE.

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)

1-hydroxy-4-Methyl-6-(2,4,4-triMethylpentyl)pyridin-2(1H)-one-2-aMinoethanol (1:1)

Pyridine-aMino ethanol

1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone·2-aminoethanol

2-Aminoethanol/1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone,(1:1)

Piroctone Olamine (200 mg)

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt

PiroCLone olaMine

LGB-PO

OCTO

1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one

4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone

Piroctone olamine/octopirox

Piroctone Olamine &gt

Piroctone ethanolamine

2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd.with 2-aminoethanol (1:1)OTHER CA INDEX NAMES:Ethanol, 2-amino-, compd. with1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1)

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine

Sinobio Anti Dangdruff Piroctone Olamine Oct for Shampoo CAS?68890-66-4?Octopirox

Piroctone Olamine (1544406)

Jarguard OCT Piroctone Oleamine

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt

Pirotone Oleamine

HYDROXYPYRIDINONE（OCT）

Piroctone olamine analytical standard, ≥99%

1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)

Piroctone Olamine (PO

1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl)pyridin-2-one (Piroctone olamine)

Piroctone ethanolamine salt

HYDROXYPYRIDINONE（OCT）/Piroctone olamine

1-Hydroxy-4-methy1-6(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine

HIC-cosmetics-RM

68890-66-4

68890-64-4

951-78-4

C14H23NO2C2H7NOC16H30N2O3

C14H23NO2C2H7NO

C14H23NO2C2H7NOC16H30

bacteriostatic and fungistatic