ChemicalBook > CAS DataBase List > 2-Chloro-4-methylpyrimidine
2-Chloro-4-methylpyrimidine
- Product Name
- 2-Chloro-4-methylpyrimidine
- CAS No.
- 13036-57-2
- Chemical Name
- 2-Chloro-4-methylpyrimidine
- Synonyms
- chloro-4-MethylpyriMidine;2-CHLORO-4-METHYLPYRIMIDINE;2-Chloro-6-methylpyrimidine;2-Chloro-4-methyl-1,3-diazine;Pyrimidine, 2-chloro-4-methyl-;2-CHLORO-4-METHYLPYRIMIDINE 98%;2-Chloro-4-methylpyrimidine >2-Chloro-4-methylpyrimidine ISO 9001：2015 REACH;Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI)
- CBNumber
- CB6434803
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 13036-57-2.mol
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2-Chloro-4-methylpyrimidine Property
- Melting point:
- 35-36°C
- Boiling point:
- 94°C/17mmHg(lit.)
- Density
- 1.234±0.06 g/cm3(Predicted)
- Flash point:
- 98℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform
- form
- Solid
- pka
- -0.93±0.20(Predicted)
- color
- Pale Yellow to Beige
- Sensitive
- Moisture Sensitive
- Stability:
- Toxic
- InChI
- InChI=1S/C5H5ClN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3
- InChIKey
- BHAKRVSCGILCEW-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C)=N1
- CAS DataBase Reference
- 13036-57-2(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-41-37/38
- Safety Statements
- 26-39
- WGK Germany
- 3
- TSCA
- N
- HazardClass
- IRRITANT
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 741116
- Product name
- 2-Chloro-4-methylpyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $69
- Updated
- 2023/01/07
TCI Chemical
- Product number
- C2631
- Product name
- 2-Chloro-4-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2631
- Product name
- 2-Chloro-4-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $165
- Updated
- 2025/07/31
TRC
- Product number
- C369530
- Product name
- 2-Chloro-4-methylpyrimidine
- Packaging
- 25g
- Price
- $195
- Updated
- 2021/12/16
TRC
- Product number
- C369530
- Product name
- 2-Chloro-4-methylpyrimidine
- Packaging
- 100g
- Price
- $515
- Updated
- 2021/12/16
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2-Chloro-4-methylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.
Application
2-chloro-4-methylpyrimidine could be used to synthesis 4-Methyl-2-vinylpyrimidine which is a intermediate of pyrimidinyl trans-cyclopropane carboxylic acid (rac-1)[1].
Synthesis
5424-21-5
13036-57-2
Step A: Synthesis of 2-chloro-4-methylpyrimidine To a vigorously stirred slurry containing 50.0 g (0.31 mol) of 2,6-dichloro-4-methylpyrimidine, 250 mL of ethanol (EtOH), and 250 mL of water, 41 g (0.63 mol) of zinc powder and 0.78 g (3.08 mmol) of iodine were sequentially added. The reaction mixture was heated to reflux at 70°C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to remove ethanol and subsequently extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to remove solvent. The residue was purified by silica gel column chromatography using a hexane/DCM solvent mixture as eluent, resulting in 20.6 g (53% yield) of 2-chloro-4-methylpyrimidine as a white solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 400 MHz) δ 8.59 (d, 1H, J=4.9 Hz), 7.44 (d, 1H, J=4.9 Hz), and 3.29 (s, 3H), and ESIMS: 129.11 (M+H+).
References
[1] M. Fray. “N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid.” Organic Process Research &Development 19 1 (2023).
2-Chloro-4-methylpyrimidine Preparation Products And Raw materials
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Preparation Products
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View Lastest Price from 2-Chloro-4-methylpyrimidine manufacturers
Zison Pharmaceutical (Shandong) Co., Ltd.
- Product
- 2-Chloro-4-methylpyrimidine 13036-57-2
- Price
- US $0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.9%
- Supply Ability
- 40-80kgs
- Release date
- 2024-05-24
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- 2-Chloro-4-methylpyrimidine 13036-57-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-12
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- 2-Chloro-4-methylpyrimidine 13036-57-2
- Price
- US $50.00-500.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30
13036-57-2, 2-Chloro-4-methylpyrimidineRelated Search:
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2-CHLORO-4-METHYL-THIAZOLE
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2,4-Dichloro-6-methyl-5-nitropyrimidine
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2,4-Dichloro-6-methylpyrimidine
METHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE,Methyl 2-chloro-4-methylpyrimidine-6-carboxylate, HPLC +97%
Difluorochloromethane