3-Methyl-8-quinolinesulphonyl chloride

Product Name: 3-Methyl-8-quinolinesulphonyl chloride
CAS No.: 74863-82-4
Chemical Name: 3-Methyl-8-quinolinesulphonyl chloride
Synonyms: Argatroban Impurity 29;Argatraban Intermediate;Argatraban Intermediate -2;3-Methylquinoline-8-sulfonyl;8-CHLOROSULFONYL-3-METHYLQUINOLINE;3-METHYL-8-QUINOLINESULFONYL CHLORIDE;3-methylquinoline-3-sulfonyl chloride;8-Quinolinesulfonyl chloride, 3-methyl-;3-METHYL-8-QUINOLINE SULPHONYL CHLORIDE;3-methyl quinoline-8-sulphonyl chloride
CBNumber: CB6460864
Molecular Formula: C10H8ClNO2S
Formula Weight: 241.69
MOL File: 74863-82-4.mol

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3-Methyl-8-quinolinesulphonyl chloride Property

Melting point:: 158-159°C
Boiling point:: 371.5±27.0 °C(Predicted)
Density: 1.424±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form: Solid
pka: 0.82±0.28(Predicted)
color: White to Pale Brown
Stability:: Moisture Sensitive - Store Under Inert Atmosphere
InChI: InChI=1S/C10H8ClNO2S/c1-7-5-8-3-2-4-9(15(11,13)14)10(8)12-6-7/h2-6H,1H3
InChIKey: XCMAYGDQKTWICK-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2S(Cl)(=O)=O)C=C(C)C=1
CAS DataBase Reference: 74863-82-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26-24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M325967
Product name: 3-Methyl-8-quinolinesulfonylChloride
Packaging: 5g
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: P808
Product name: 3-Methyl-8-quinolinesulphonylchloride
Packaging: 250mg
Price: $15
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK195326
Product name: 3-Methyl-8-quinolinesulfonylchloride
Purity: 98%
Packaging: 1g
Price: $309
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010735
Product name: 3-METHYL-8-QUINOLINESULFONYL CHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $692.46
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12205
Product name: 3-Methyl-8-quinolinesulfonylChloride
Packaging: 1g
Price: $875
Updated: 2021/12/16

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3-Methyl-8-quinolinesulphonyl chloride Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Brown Solid

Uses

3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.

Synthesis

612-58-8

74863-82-4

The general procedure for the synthesis of 3-methylquinoline-8-sulfonyl chloride from 3-methylquinoline was as follows: 3-methylquinoline (5.2 g, 36 mmol) was slowly added to 9 mL (135 mmol) of chlorosulfonic acid at 0°C with reference to U.S. Patent Nos. 4,522,576 and 5,332,822. After removing the ice bath, the reaction mixture was stirred at 100 °C overnight. After the reaction mixture was cooled to room temperature, 3.3 mL (45 mmol) of thionyl chloride was added, followed by heating at 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and carefully quenched with ice (note: this step is highly reactive). The reaction mixture was diluted with 100 mL of water and extracted with dichloromethane (100 mL). The organic phase was washed with water, dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was ground with a solvent mixture of dichloromethane/ether to give 1.58 g (18% yield) of 3-methylquinoline-8-sulfonyl chloride as a brown solid. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 9.17-9.29 (m, 2H), 8.32-8.38 (m, 2H), 7.96 (dd, 1H, J = 7Hz), and 2.51 (t, 3H, J = 2Hz).

References

[1] Patent: US6235778, 2001, B1

3-Methyl-8-quinolinesulphonyl chloride Preparation Products And Raw materials

Raw materials

Toluene 3-Methylquinoline Chlorosulfonic acid Phosphorus pentachloride Diethyl ether Dichloromethane Thionyl chloride

Preparation Products

Argatroban

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3-Methyl-8-quinolinesulphonyl chloride Suppliers

Canada 2 China 236 Europe 1 France 1 Germany 1 India 7 United Kingdom 3 United States 15 Global 266

Accela ChemBio Inc.

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View Lastest Price from 3-Methyl-8-quinolinesulphonyl chloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-10-20

Changzhou waston chemical technology Co.,Ltd

Product: 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 90%,97%
Supply Ability: As your request
Release date: 2025-03-19

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-19

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74863-82-4 3-Methyl-8-quinolinesulphonyl chloride

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3-methylquinoline-3-sulfonyl chloride

3-Methylquinoline-8-sulfonyl

74863-82-4

2216-06-9

C10H8NO2ClS

SULFONYLHALIDE

Aromatics Compounds

Aromatics

Sulfonyl Chlorides

Sulfur & Selenium Compounds