L-745,870 TRIHYDROCHLORIDE
- Product Name
- L-745,870 TRIHYDROCHLORIDE
- CAS No.
- 158985-00-3
- Chemical Name
- L-745,870 TRIHYDROCHLORIDE
- Synonyms
- 3HCl;L 745870;L 745870,L745870;L-745,870 trihydroch;L-745,870 TRIHYDROCHLORIDE;3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-;3-(4-[4-CHLOROPHENYL]PIPERAZIN-1-YL)-METHYL-1H-PYRROLO[2,3-B]PYRIDINE TRIHYDROCHLORIDE
- CBNumber
- CB6481216
- Molecular Formula
- C18H19ClN4
- Formula Weight
- 326.82
- MOL File
- 158985-00-3.mol
L-745,870 TRIHYDROCHLORIDE Property
- Boiling point:
- 571.4±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO:16.5(Max Conc. mg/mL);50.49(Max Conc. mM)
- pka
- 8.20±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1002
- Product name
- L-745,870trihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $634
- Updated
- 2021/12/16
- Product number
- API0003103
- Product name
- 3-((4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)METHYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $665.81
- Updated
- 2021/12/16
- Product number
- API0003103
- Product name
- 3-((4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)METHYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1073.29
- Updated
- 2021/12/16
- Product number
- API0003103
- Product name
- 3-((4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)METHYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1529.85
- Updated
- 2021/12/16
- Product number
- CS-0003281
- Product name
- L-745870
- Purity
- 99.88%
- Packaging
- 5mg
- Price
- $82
- Updated
- 2021/12/16
L-745,870 TRIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.
Definition
ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines.
Biological Activity
A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.