Lonidamine
Description References- Product Name
- Lonidamine
- CAS No.
- 50264-69-2
- Chemical Name
- Lonidamine
- Synonyms
- dica;lonidamin;af1890;LONIDAMINE;doridamina;Lonidnmine;LONIDAMING;AF-1890：DICA;Lonidamine, >=99%;DICLONDAZOLIC ACID
- CBNumber
- CB6493965
- Molecular Formula
- C15H10Cl2N2O2
- Formula Weight
- 321.16
- MOL File
- 50264-69-2.mol
Lonidamine Property
- Melting point:
- 207-209°C
- Boiling point:
- 537.9±45.0 °C(Predicted)
- Density
- 1.4835 (rough estimate)
- refractive index
- 1.6070 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- pka
- 3.00±0.10(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
- InChIKey
- WDRYRZXSPDWGEB-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=C(Cl)C=C2Cl)C2=C(C=CC=C2)C(C(O)=O)=N1
- CAS DataBase Reference
- 50264-69-2(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 60-22-40
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- NK7886000
- HS Code
- 29339900
- Toxicity
- LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H351Suspected of causing cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- L4900
- Product name
- Lonidamine
- Purity
- mitochondrial hexokinase inhibitor
- Packaging
- 5mg
- Price
- $182
- Updated
- 2025/07/31
- Product number
- L4900
- Product name
- Lonidamine
- Purity
- mitochondrial hexokinase inhibitor
- Packaging
- 25mg
- Price
- $436.1
- Updated
- 2025/07/31
- Product number
- L0283
- Product name
- Lonidamine
- Packaging
- 250MG
- Price
- $131
- Updated
- 2025/07/31
- Product number
- 14640
- Product name
- Lonidamine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 14640
- Product name
- Lonidamine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $77
- Updated
- 2024/03/01
Lonidamine Chemical Properties,Usage,Production
Description
Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/
https://en.wikipedia.org/wiki/Lonidamine
Description
Lonidamine is an antineoplastic agent reportedly effective for the treatment of various cancers, including lung, breast, prostate and brain tumors. Its clinical effect appears to be associated with changes in cellular energy metabolism.
Originator
Angelini (Italy)
Uses
contraceptive, spermicidal
Definition
ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.
brand name
Doridamina
Biological Activity
Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro .
Biochem/physiol Actions
Inhibits the energy metabolism of neoplastic cells by interfering with hexokinase and disrupting uncoupler-stimulated mitochondrial electron transport; damages cell and mitochondrial membranes.
storage
Room temperature
References
[1] MARIA TERESA GATTO . Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids[J]. Contraception, 2002, 65 4: Pages 277-278. DOI:10.1016/s0010-7824(02)00289-5
[2] A FLORIDI. Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.[J]. Cancer research, 1981, 41 11 Pt 1: 4661-4666.
[3] LUIGI RAVAGNAN. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore[J]. Oncogene, 1999, 18 16: 2537-2546. DOI:10.1038/sj.onc.1202625
[4] H BEN-HORIN. Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies.[J]. Cancer research, 1995, 55 13: 2814-2821.
[5] KAVINDRA NATH . Mechanism of antineoplastic activity of lonidamine[J]. Biochimica et biophysica acta. Reviews on cancer, 2016, 1866 2: Pages 151-162. DOI:10.1016/j.bbcan.2016.08.001
Lonidamine Preparation Products And Raw materials
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View Lastest Price from Lonidamine manufacturers
- Product
- Lonidamine 50264-69-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min HPLC
- Supply Ability
- 1000G
- Release date
- 2021-06-24
- Product
- Lonidamine 50264-69-2
- Price
- US $9.90-7.70/g
- Min. Order
- 10g
- Purity
- 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
- Supply Ability
- 1000kgs
- Release date
- 2022-02-22
- Product
- Lonidamine 50264-69-2
- Price
- US $10.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 1000KG
- Release date
- 2021-12-21