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Ceftibuten dihydrate

Product Name
Ceftibuten dihydrate
CAS No.
118081-34-8
Chemical Name
Ceftibuten dihydrate
Synonyms
Cetb;Cedax;Seftem;D02121;Sch-39720;Cedax (tn);Cedax-13C3;Seftem (tn);S 7432-13C3;Cedax dihydrate
CBNumber
CB6496825
Molecular Formula
C15H16N4O7S2
Formula Weight
428.43
MOL File
118081-34-8.mol
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Ceftibuten dihydrate Property

Melting point:
>180°C (dec.)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Water (Slightly)
form 
Solid
color 
Pale Yellow to Light Orange
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25334
Product name
Ceftibuten (hydrate)
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
25334
Product name
Ceftibuten (hydrate)
Purity
≥98%
Packaging
25mg
Price
$188
Updated
2024/03/01
Cayman Chemical
Product number
25334
Product name
Ceftibuten (hydrate)
Purity
≥98%
Packaging
50mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
25334
Product name
Ceftibuten (hydrate)
Purity
≥98%
Packaging
100mg
Price
$672
Updated
2024/03/01
TRC
Product number
C244500
Product name
Ceftibuten Hydrate
Packaging
2g
Price
$1755
Updated
2021/12/16
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Ceftibuten dihydrate Chemical Properties,Usage,Production

Chemical Properties

Light-Yellow Solid

Uses

Ceftibuten dihydrate, one of the third-generation cephalosporin antibiotic is effectively used in curing several infectious diseases.

Uses

Ceftibuten Dihydrate is used in preparation of Ceftibuten crystal.

Definition

ChEBI: Ceftibuten dihydrate is the dihydrate of ceftibuten. It is used as an orally administered treatment for urinary-tract and respiratory-tract infections. It has a role as an antibacterial drug. It contains a ceftibuten.

Biological Activity

Ceftibuten is an orally bioavailable broad-spectrum cephalosporin antibiotic that inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively).1,2 Ceftibuten is also active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively). In vivo, ceftibuten reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection by 50% when administered subcutaneously at doses of 0.125, 2, 1,024, and >512 mg/kg, respectively.3 Formulations containing ceftibuten have been used in the treatment of bacterial infections including bronchitis, pneumonia, and enteritis.

Pharmacokinetics

Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Ceftibuten dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ceftibuten dihydrate Suppliers

Canada 1 China 120 Germany 1 India 6 United States 18 Global 146
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Ceftibuten dihydrate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Ceftibuten dihydrate 118081-34-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-18
Hebei Zhanyao Biotechnology Co. Ltd
Product
Ceftibuten dihydrate 118081-34-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-12
Shaanxi Dideu Medichem Co. Ltd
Product
Ceftibuten dihydrate 118081-34-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23

118081-34-8, Ceftibuten dihydrateRelated Search:

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  • Cedax dihydrate
  • CEDAX DIHYDRATE;SCH-39720 DIHYDRATE
  • Sch-39720 dihydrate
  • (+)-(6r,7r)-7-[2-(2-amino-1,3-thiazol-4-yl)-4-carboxy-2-butenamide]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate
  • Cedax
  • Cedax (tn)
  • Ceftibuten (jp15)
  • Cetb
  • D02121
  • Seftem
  • Seftem (tn)
  • Sch-39720
  • Cephalosporins cloth temple
  • Ceftibuten Hydrate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[2-(2-aMino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]aMino]-8-oxo-,dihydrate, [6R-[6a,7b(Z)]]- (9CI)
  • [6R-[6α,7β(Z)]]-7-[[2-(2-AMino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Dihydrate
  • [6R-[6α,7β(Z)]]-7-[[2-(2-AMino-4-thiazolyl)-4-carboxy-1-oxo-2-(butenyl-13C3)]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • Cedax-13C3
  • Cephalosporin 7432-S-13C3
  • S 7432-13C3
  • Ceftibuten 2-hydrate
  • ceftibuten dihydrate
  • (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-Yl)-4-Carboxybut-2-Enoylamino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Dihydrate
  • Ceftibuten dehydrate
  • (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-4-carboxybut-2-enamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate
  • Ceftibuten dihydrate USP/EP/BP
  • Ceftibuten dihydrateQ: What is Ceftibuten dihydrate Q: What is the CAS Number of Ceftibuten dihydrate Q: What is the storage condition of Ceftibuten dihydrate Q: What are the applications of Ceftibuten dihydrate
  • Ceftibuten dihydrate Powder USP Standard
  • Cefobuxene dihydrate
  • 118081-34-8
  • 118081-34-1
  • C15H14N4O6S22H2O
  • C15H18N4O8S2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
  • Heterocycles
  • Sulfur & Selenium Compounds