Ceftibuten dihydrate
- Product Name
- Ceftibuten dihydrate
- CAS No.
- 118081-34-8
- Chemical Name
- Ceftibuten dihydrate
- Synonyms
- Cetb;Cedax;Seftem;D02121;Sch-39720;Cedax (tn);Cedax-13C3;Seftem (tn);S 7432-13C3;Cedax dihydrate
- CBNumber
- CB6496825
- Molecular Formula
- C15H16N4O7S2
- Formula Weight
- 428.43
- MOL File
- 118081-34-8.mol
Ceftibuten dihydrate Property
- Melting point:
- >180°C (dec.)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Solid
- color
- Pale Yellow to Light Orange
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235Keep cool.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25334
- Product name
- Ceftibuten (hydrate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 25334
- Product name
- Ceftibuten (hydrate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 25334
- Product name
- Ceftibuten (hydrate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 25334
- Product name
- Ceftibuten (hydrate)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $672
- Updated
- 2024/03/01
- Product number
- C244500
- Product name
- Ceftibuten Hydrate
- Packaging
- 2g
- Price
- $1755
- Updated
- 2021/12/16
Ceftibuten dihydrate Chemical Properties,Usage,Production
Chemical Properties
Light-Yellow Solid
Uses
Ceftibuten dihydrate, one of the third-generation cephalosporin antibiotic is effectively used in curing several infectious diseases.
Uses
Ceftibuten Dihydrate is used in preparation of Ceftibuten crystal.
Definition
ChEBI: Ceftibuten dihydrate is the dihydrate of ceftibuten. It is used as an orally administered treatment for urinary-tract and respiratory-tract infections. It has a role as an antibacterial drug. It contains a ceftibuten.
Biological Activity
Ceftibuten is an orally bioavailable broad-spectrum cephalosporin antibiotic that inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively).1,2 Ceftibuten is also active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively). In vivo, ceftibuten reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection by 50% when administered subcutaneously at doses of 0.125, 2, 1,024, and >512 mg/kg, respectively.3 Formulations containing ceftibuten have been used in the treatment of bacterial infections including bronchitis, pneumonia, and enteritis.
Pharmacokinetics
Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Ceftibuten dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Ceftibuten dihydrate Suppliers
View Lastest Price from Ceftibuten dihydrate manufacturers
- Product
- Ceftibuten dihydrate 118081-34-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18
- Product
- Ceftibuten dihydrate 118081-34-8
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-12
- Product
- Ceftibuten dihydrate 118081-34-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-29