ChemicalBook > CAS DataBase List > 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- Product Name
- 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- CAS No.
- 136632-32-1
- Chemical Name
- 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- Synonyms
- ALLM (Calpain Inhibitor);ALLM (Ac-Leu-Leu-Met-CHO);N-acetyl-Leu-Leu-methional;Calpain Inhibitor II, ALLM;Calpain Inhibitor II powder;ALLM (Calpain Inhibitor) 95% purity;25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL)
- CBNumber
- CB6500395
- Molecular Formula
- C19H35N3O4S1
- Formula Weight
- 401.56
- MOL File
- Mol file
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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Property
- storage temp.
- −20°C
- solubility
- Soluble in ethanol at 20mg/ml
- form
- powder
- color
- white
- BRN
- 7693643
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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N-Bromosuccinimide Price
Alfa Aesar
- Product number
- J62491
- Product name
- Calpain Inhibitor II, 95+%
- Packaging
- 25mg
- Price
- $489
- Updated
- 2023/06/20
TRC
- Product number
- A189693
- Product name
- N-Acetyl-L-leucyl-L-leucyl-L-methional
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A2603
- Product name
- CalpainInhibitorII,ALLM
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A2603
- Product name
- CalpainInhibitorII,ALLM
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A2603
- Product name
- CalpainInhibitorII,ALLM
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $80
- Updated
- 2021/12/16
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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties,Usage,Production
Description
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.
Uses
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Uses
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
Definition
ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.
References
1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials
Raw materials
Preparation Products
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136632-32-1, 25 MG CALPAIN INHIBITOR IIRESEARCH GRADERelated Search:
1 VIAL PROTEASE-INHIBITOR-MIX FY
PROTEASE INHIBITOR COCKTAIL, W/EDTA
1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG)
TRYPSIN INHIBITOR
Urinary Trypsin Inhibitor
DISPASE
ACHROMOPEPTIDASE
Trypsin
MG-115
trysin-chymotrypsin
Basic protease
AC-LEU-VAL-PHE-ALDEHYDE
Protease Inhibitor Cocktail (For Bacterial Cell, EDTA Free)
Neutrophil Elastase Inhibitor Screening Kit
HumanUrinaryTrypsinInhibitor(Uti)
CALPAIN INHIBITOR I
Calpain Inhibitor I
CALPAIN INHIBITOR II