25 MG CALPAIN INHIBITOR IIRESEARCH GRADE

Product Name: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
CAS No.: 136632-32-1
Chemical Name: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
Synonyms: ALLM (Calpain Inhibitor);ALLM (Ac-Leu-Leu-Met-CHO);N-acetyl-Leu-Leu-methional;Calpain Inhibitor II, ALLM;Calpain Inhibitor II powder;ALLM (Calpain Inhibitor) 95% purity;25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL)
CBNumber: CB6500395
Molecular Formula: C19H35N3O4S1
Formula Weight: 401.56
MOL File: Mol file

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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Property

storage temp.: −20°C
solubility: Soluble in ethanol at 20mg/ml
form: powder
color: white
BRN: 7693643
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62491
Product name: Calpain Inhibitor II, 95+%
Packaging: 25mg
Price: $489
Updated: 2023/06/20

TRC

Product number: A189693
Product name: N-Acetyl-L-leucyl-L-leucyl-L-methional
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

ApexBio Technology

Product number: A2603
Product name: CalpainInhibitorII,ALLM
Packaging: 25mg
Price: $200
Updated: 2021/12/16

ApexBio Technology

Product number: A2603
Product name: CalpainInhibitorII,ALLM
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A2603
Product name: CalpainInhibitorII,ALLM
Packaging: 10mM(in 1mL DMSO)
Price: $80
Updated: 2021/12/16

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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties,Usage,Production

Description

ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Uses

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

Definition

ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials

Raw materials

Preparation Products

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25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Suppliers

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136632-32-1, 25 MG CALPAIN INHIBITOR IIRESEARCH GRADERelated Search:

1 VIAL PROTEASE-INHIBITOR-MIX FY PROTEASE INHIBITOR COCKTAIL, W/EDTA 1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG) TRYPSIN INHIBITOR Urinary Trypsin Inhibitor DISPASE ACHROMOPEPTIDASE Trypsin MG-115 trysin-chymotrypsin Basic protease AC-LEU-VAL-PHE-ALDEHYDE Protease Inhibitor Cocktail (For Bacterial Cell, EDTA Free) Neutrophil Elastase Inhibitor Screening Kit HumanUrinaryTrypsinInhibitor(Uti) CALPAIN INHIBITOR I Calpain Inhibitor I CALPAIN INHIBITOR II

Calpain Inhibitor II, ALLM

CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL)

N-acetyl-Leu-Leu-methional

ALLM (Calpain Inhibitor) 95% purity

ALLM (Calpain Inhibitor)

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE

Calpain Inhibitor II powder

ALLM (Ac-Leu-Leu-Met-CHO)

136632-32-1

Protease

Nitric Oxide and Cell

A to C

Aldehydes

and Substrates

Apoptosis Enzymes

Application Index

Bioactive Small Molecules

Biochemicals and Reagents

Building Blocks

C13-C60

Calpain

Calpain and Proteasome Inhibitors

ProteasomeInhibitors

Intracellular Protein Degradation

Lysosomal Proteases

Substrates

Calpain I

Calpain I Inhibitors

Calpain II

Calpain II Inhibitors

Carbonyl Compounds

Cathepsin B

Cathepsin/Granzyme Inhibitors &amp

C-CH

Cell Biology

Cell Signaling and Neuroscience

Cell Signaling Enzymes

Chemical Synthesis

Endoplasmic Reticulum Stress

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Enzymes

Inhibitors