VU0453379
- Product Name
- VU0453379
- CAS No.
- 1638646-27-1
- Chemical Name
- VU0453379
- Synonyms
- VU0453379;1H-Pyrido[3,4-b]indole-4-carboxamide, 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-
- CBNumber
- CB65838150
- Molecular Formula
- C26H34N4O2
- Formula Weight
- 434.57
- MOL File
- 1638646-27-1.mol
VU0453379 Property
- Boiling point:
- 671.8±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.46±0.20(Predicted)
- color
- Off-white to light yellow
- Water Solubility
- H2O: 20mg/mL, clear
N-Bromosuccinimide Price
- Product number
- SML1357
- Product name
- VU0453379 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $380
- Updated
- 2025/07/31
VU0453379 Chemical Properties,Usage,Production
Uses
VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].
Biological Activity
VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.
References
[1] Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. DOI:10.1021/jm501375c
VU0453379 Preparation Products And Raw materials
Raw materials
Preparation Products
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