VU-0486321

Product Name: VU-0486321
CAS No.: 1816301-67-3
Chemical Name: VU-0486321
Synonyms: VU-0486321;2-Furancarboxamide, N-[3-chloro-4-(4-fluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-3-methyl-
CBNumber: CB59440912
Molecular Formula: C20H12ClFN2O4
Formula Weight: 398.77
MOL File: 1816301-67-3.mol

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VU-0486321 Property

Density: 1.528±0.06 g/cm3(Predicted)
form: Solid
pka: 11.68±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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VU-0486321 Chemical Properties,Usage,Production

Description

VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/mikg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).

Uses

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

References

[1] Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs

VU-0486321 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU-0486321 Suppliers

China 3 United States 2 Global 5

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
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NanJing Xienuo bio Co.,Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
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VU-0486321

2-Furancarboxamide, N-[3-chloro-4-(4-fluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-3-methyl-

1816301-67-3