VU 0463841

Product Name: VU 0463841
CAS No.: 1439095-16-5
Chemical Name: VU 0463841
Synonyms: VU0463841;VU-0463841;VU 0463841
CBNumber: CB011075608
Molecular Formula: C13H8ClFN4O
Formula Weight: 290.68
MOL File: 1439095-16-5.mol

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Hazard and Precautionary Statements (GHS)

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VU 0463841 Chemical Properties,Usage,Production

Description

VU0463841 is a negative allosteric modulators of mGlu5.

Uses

VU0463841 is a potent, selective and brain-penetrant mGlu5 negative allosteric modulator (NAM) with an IC50 of 13 nM. VU0463841 is ineffective against mGlu1-4 and mGlu7-8. VU0463841 has the potential for the Cocaine addiction research[1].

IC 50

mGlu5 Receptor: 13 nM (IC₅₀)

References

[1] Russell J Amato, et al. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013 Aug 21;4(8):1217-28. DOI:10.1021/cn400070k

VU 0463841 Preparation Products And Raw materials

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Preparation Products

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VU 0463841 Suppliers

China 2 United States 2 Global 4

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Wuhan Han Sheng New Material Technology Co.，Ltd

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TargetMol Chemicals Inc.

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1439095-16-5, VU 0463841Related Search:

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VU 0463841

VU0463841

VU-0463841

1439095-16-5