VU0453379

Product Name: VU0453379
CAS No.: 1638646-27-1
Chemical Name: VU0453379
Synonyms: VU0453379;1H-Pyrido[3,4-b]indole-4-carboxamide, 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-
CBNumber: CB65838150
Molecular Formula: C26H34N4O2
Formula Weight: 434.57
MOL File: 1638646-27-1.mol

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VU0453379 Property

Boiling point:: 671.8±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 13.46±0.20(Predicted)
color: Off-white to light yellow
Water Solubility: H2O: 20mg/mL, clear

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Hazard and Precautionary Statements (GHS)

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VU0453379 Chemical Properties,Usage,Production

Biological Activity

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

VU0453379 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU0453379 Suppliers

China 5 United States 2 Global 7

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Email: support@targetmol.com
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1638646-27-1, VU0453379Related Search:

VU0453595 Ethanone, 1-[6,7-dihydro-2-(phenoxymethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl]- 2-[5-(2-Fluorophenyl)-1H-pyrazol-3-yl]-phenol VU 0463841 [Hexahydro-5-(4-pyridinyl)pyrrolo[3,4-c]pyrrol-2(1H)-yl][1-(5-isoquinolinylsulfonyl)-3-azetidinyl]-Methanone N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide VU 0364439 5-[1-(2-ethoxyphenyl)sulfonylazetidin-3-yl]-3-thiophen-3-yl-1,2,4-oxadiazole VU 0360223 2(5H)-Furanone, 3-(3-fluorophenyl)-4-(4-methoxyphenyl)- VU 0360172 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide Urea, N-(3,4-difluorophenyl)-N'-[3-methyl-1-(phenylmethyl)-1H-pyrazol-5-yl]- VU-0486321 VU0238441 VU0483605

VU0453379

1H-Pyrido[3,4-b]indole-4-carboxamide, 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-

1638646-27-1