ChemicalBook > CAS DataBase List > L-(-)-Histidinol dihydrochloride

L-(-)-Histidinol dihydrochloride

Product Name
L-(-)-Histidinol dihydrochloride
CAS No.
1596-64-1
Chemical Name
L-(-)-Histidinol dihydrochloride
Synonyms
(S)-B2;(±)-Midodrin;H-HIS-OL 2HCL;L-HISTIDINOL 2 HCL;L-(-)-Histidinol dih;L-HISTIDINE DIHYDROCHLORIDE;L-Histidinol·2hydrochloride;L-HISTIDINOL DIHYDROCHLORIDE;L-Histidinol (hydrochloride);L-histidinol dihydrochloroide
CBNumber
CB6666879
Molecular Formula
C6H13Cl2N3O
Formula Weight
214.09
MOL File
1596-64-1.mol
More
Less

L-(-)-Histidinol dihydrochloride Property

Melting point:
198-201 °C (dec.)(lit.)
alpha 
-3 º (C=2, H2O 24 ºC)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
form 
Crystalline Powder
color 
White to slightly beige
BRN 
3914853
InChIKey
FRCAFNBBXRWXQA-XRIGFGBMSA-N
CAS DataBase Reference
1596-64-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39-36/37-22
WGK Germany 
3
RTECS 
NI8260000
HS Code 
29332900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
1g
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
5g
Price
$741
Updated
2024/03/01
Cayman Chemical
Product number
18739
Product name
L-Histidinol (hydrochloride)
Purity
≥95%
Packaging
500mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
18739
Product name
L-Histidinol (hydrochloride)
Purity
≥95%
Packaging
1g
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
H6647
Product name
L-Histidinol dihydrochloride
Purity
≥98 (TLC)
Packaging
10mg
Price
$38.1
Updated
2024/03/01
More
Less

L-(-)-Histidinol dihydrochloride Chemical Properties,Usage,Production

Description

L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.

Chemical Properties

white to slightly beige crystalline powder

Uses

A metabolite within Histidine metabolism.

Definition

ChEBI: L-Histidinol dihydrochloride is an aralkylamine.

in vitro

preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].

in vivo

l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

References

[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.

L-(-)-Histidinol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-(-)-Histidinol dihydrochloride Suppliers

Austria 1 Belgium 1 Canada 1 China 98 Germany 2 India 6 Japan 3 South Korea 1 Switzerland 3 United Kingdom 5 United States 32 Global 153
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
More
Less

View Lastest Price from L-(-)-Histidinol dihydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
L-(-)-Histidinol dihydrochloride 1596-64-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-08
Career Henan Chemical Co
Product
L-(-)-Histidinol dihydrochloride 1596-64-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

1596-64-1, L-(-)-Histidinol dihydrochlorideRelated Search:

Tris(hydroxymethyl)aminomethane 6-Aminocaproic acid ALTRENOGEST 1-Propanol Glycine Ketorolac tromethamine Fosfomycin tromethamine TRISTEARIN Glycinamide hydrochloride Imidazole Dihydrochloride N'-Methyl-L-histidine methyl ester L-HISTIDINE DIHYDROCHLORIDE Methyl L-histidinate dihydrochloride (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride H-HIS(BZL)-OME 2 HCL D(+)-HISTIDINOL DIHYDROCHLORIDE L-Histidine

  • L(-)-Histidinol dihydrochloride,99%
  • (S)-β-amino-1H-imidazole-4-propanol dihydrochloride
  • L-HISTIDINOL 2 HCL
  • L-HISTIDINOL DIHYDROCHLORIDE
  • L-HISTIDINE DIHYDROCHLORIDE
  • L-BETA-AMINO-1H-IMIDAZOLE-4-PROPANOL DIHYDROCHLORIDE
  • (L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
  • HISTIDINOL Dihydrochloride, L-(RG)
  • L-Histidinol dihydrochloride,β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride
  • L-(-)-Histidinol dih
  • (S)-Histidinol Dihydrochloride
  • (βS)-β-AMino-1H-iMidazole-5-propanol Hydrochloride
  • <SC>L</SC>-Histidinol dihydrochloride
  • L-Histidinol (hydrochloride)
  • L-Histidinol dihydrochloride≥ 99% (TLC)
  • H-HIS-OL 2HCL
  • HISTIDINOL DIHYDROCHLORIDE, L-
  • (S)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
  • S(+)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
  • (S)-2-AMINO-3-(1H-IMIDAZOL-4-YL)PROPAN-1-OL DIHYDROCHLORIDE
  • beta-amino-,dihydrochloride,(s)-1h-imidazole-4-propano
  • beta-amino-imidazole-4-propanodihydrochloride
  • beta-aminoimidazole-4-propanoldihydrochloride
  • (S)-beta-amino-1H-imidazole-4-propanol dihydrochloride
  • Aminoimidazole-4-propanol dihydrochloride
  • ((L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL)
  • Imidazole-4-propanol, beta-amino, dihydrochloride.
  • β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride
  • L-Histidinol·2hydrochloride
  • 2-amino-3-(1H-imidazol-5-yl)-1-propanol dihydrochloride
  • 1H-Imidazole-5-propanol, β-amino-, hydrochloride (1:2), (βS)-
  • (S)-2-Amino-3-(1h-imidazol-5-yl)propan-1-ol hcl
  • L-histidinol dihydrochloroide
  • L-(-)-Histidinol dihydrochloride USP/EP/BP
  • (S)-β-amino-1H-imidazole-4-propanol dihydrochloride
  • (S)-B2
  • -amino-1H-imidazole-4-propanol dihydrochloride
  • (±)-Midodrin
  • 1H-Imidazole-5-propanol, b-amino-, hydrochloride, (S)-
  • (S)-2-Amino-3-(1h-imidazol-5-yl)propan-1-ol?dihydrochloride
  • 1596-64-1
  • 1007-422-7
  • C6H11N3OHCl
  • AMINE
  • Peptide Synthesis
  • Specialty Synthesis
  • Metabolic Libraries
  • Metabolomics
  • Amino Acid Derivatives
  • Amino Acid Library
  • BioChemical
  • Amino Alcohols
  • Chiral Reagents
  • Heterocycles
  • Metabolites & Impurities
  • Amino hydrochloride