2-Amino-3-nitro-4-picoline
- Product Name
- 2-Amino-3-nitro-4-picoline
- CAS No.
- 6635-86-5
- Chemical Name
- 2-Amino-3-nitro-4-picoline
- Synonyms
- NSC 52453;TIMTEC-BB SBB006636;4-METHYL-3-NITRO-PYRI;2-AMINO-3-NITRO-4-PICOLINE;2-AMino-4-Methyl-3-nitrop...;2-Amino-3-nitro-4-picoline,98%;4-Methyl-3-nitro-2-pyridinamine;2-amin-3-nitro-4-methylpyridine;3-Nitro-4-methyl-2-pyridinamine;4-methyl-3-nitropyridin-2-amine
- CBNumber
- CB6671998
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 6635-86-5.mol
2-Amino-3-nitro-4-picoline Property
- Melting point:
- 136-140 °C(lit.)
- Boiling point:
- 276.04°C (rough estimate)
- Density
- 1.3682 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Crystalline Powder
- pka
- 2.97±0.47(Predicted)
- color
- Yellow
- BRN
- 139111
- InChI
- InChI=1S/C6H7N3O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3,(H2,7,8)
- InChIKey
- IKMZGACFMXZAAT-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC(C)=C1[N+]([O-])=O
- CAS DataBase Reference
- 6635-86-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2-amino-3-nitro-4-methyl-(6635-86-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 3
- F
- 10
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290084
- Product name
- 2-Amino-4-methyl-3-nitropyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $300
- Updated
- 2023/06/20
- Product number
- 290084
- Product name
- 2-Amino-4-methyl-3-nitropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $152
- Updated
- 2023/01/07
- Product number
- A1888
- Product name
- 2-Amino-4-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- A1888
- Product name
- 2-Amino-4-methyl-3-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- A616960
- Product name
- 2-Amino-4-methyl-3-nitropyridine
- Packaging
- 10g
- Price
- $970
- Updated
- 2021/12/16
2-Amino-3-nitro-4-picoline Chemical Properties,Usage,Production
Chemical Properties
light yellow crystal powder
Uses
2-Amino-4-methyl-3-nitropyridine was used in the synthesis of 2-amino-5-hydroxy-4-methyl-3-nitropyridine, 2-amino-4-hydroxymethyl-3-nitropyridine and 2-amino-4-methyl-3-nitropyridine-1-oxide by undergoing biotransformation by Cunninghamella elegans ATCC 26269.
General Description
The crystal structure of 2-amino-4-methyl-3-nitropyridine was elucidated.
Synthesis
695-34-1
21901-40-6
6635-86-5
The general procedure for the synthesis of 2-amino-4-methyl-5-nitropyridine and 4-methyl-3-nitropyridin-2-amine from 2-amino-4-methylpyridine was carried out as follows: commercially available 2-amino-4-methylpyridine (Fluka, purity >99%) was used as starting material according to the method previously described by Talik and Talik [29]. This was done as follows: 25 g of 2-amino-4-methylpyridine was dissolved in 125 cm3 concentrated sulfuric acid (Fluka, 96%). The reaction mixture was cooled to 0°C under strong stirring by adding ice mixed with sodium chloride. Subsequently, 37.5 cm3 of nitric acid (Chempur, 65%, density = 1.4 g/cm3) was slowly added, keeping the reaction temperature below 10°C. The reaction mixture was stirred under continuous cooling for 1.5 hours, followed by standing at room temperature for 1 hour. Next, the reaction mixture was sequentially heated in a water bath at 40°C for half an hour, at 60-70°C for 1 hour and in a boiling water bath for half an hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and adjusted to a weakly basic pH with ammonia. the solid product was collected by vacuum filtration. Steam distillation was utilized to separate the two nitro isomers (3-nitro and 5-nitro isomers). The more volatile 3-nitro isomer (I) was first distilled and concentrated and dried to give the pure product (10 g). The residual 5-nitro isomer (III) was collected by filtration and recrystallized from water (initial addition of sulfuric acid and activated carbon to dissolve the compound and remove impurities). After neutralization, filtration and drying, about 15 g of 5-nitroisomer (III) was obtained. 2-Amino-4-methyl-3,5-dinitropyridine (II) was prepared from 2-amino-4-methyl-5-nitropyridine (III) using a similar method (nitration and rearrangement to dinitropyridine). The residue was purified by crystallization in water to give 2-amino-4-methyl-3-nitropyridine (I) (yield: 27%, 10 g, melting point 134 °C), 2-amino-4-methyl-3,5-dinitropyridine (II) (yield: 80%, 10.4 g, melting point 197 °C) and 2-amino-4-methyl-5-nitropyridine (III) (yield: 40%, 15 g (yield: 40%, 15g, melting point 218°C). Melting points were determined using a K?fler apparatus and the chemical composition of the compounds was verified by Carlo Erba Analyzer (model 1104).
References
[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2012, vol. 96, p. 952 - 962
[2] Journal of the Chemical Society, 1954, p. 2448,2455
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 3154
[4] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[5] Journal of Molecular Structure, 2013, vol. 1043, p. 15 - 27
2-Amino-3-nitro-4-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-3-nitro-4-picoline manufacturers
- Product
- 2-Amino-3-nitro-4-picoline 6635-86-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Amino-3-nitro-4-picoline 6635-86-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Amino-3-nitro-4-picoline 6635-86-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26