Procarbazine hydrochloride
- Product Name
- Procarbazine hydrochloride
- CAS No.
- 366-70-1
- Chemical Name
- Procarbazine hydrochloride
- Synonyms
- PROCARBAZINE HCL;matulane;ibz;Mutulane;nsc-77213;nci-c01810;NSC-77213 HCl;natulanhydrochloride;ibenzmethyzinhydrochloride;PROCARBAZINE HYDROCHLORIDE
- CBNumber
- CB6678902
- Molecular Formula
- C12H20ClN3O
- Formula Weight
- 257.76
- MOL File
- 366-70-1.mol
Procarbazine hydrochloride Property
- Melting point:
- 223°C
- Density
- 8.3 g/cm3
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: ≥18mg/mL
- form
- powder
- color
- white to tan
- Water Solubility
- >=10 g/100 mL at 21.5 ºC
- Merck
- 14,7758
- BCS Class
- 3/1
- CAS DataBase Reference
- 366-70-1(CAS DataBase Reference)
- IARC
- 2A (Vol. 26, Sup 7) 1987
- EPA Substance Registry System
- Procarbazine hydrochloride (366-70-1)
Safety
- Hazard Codes
- T
- Risk Statements
- 45-61-22-68
- Safety Statements
- 53-36/37-45
- WGK Germany
- 3
- RTECS
- XS4725000
- HS Code
- 2928002500
- Toxicity
- LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H341Suspected of causing genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0036
- Product name
- Procarbazine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $97.2
- Updated
- 2024/03/01
- Product number
- 1565009
- Product name
- Procarbazine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $393
- Updated
- 2024/03/01
- Product number
- P2550
- Product name
- Procarbazine Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- P2550
- Product name
- Procarbazine Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 16133
- Product name
- Procarbazine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
Procarbazine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Chemical Properties
Procarbazine is a white to pale yellow crystal- line powder with a slight odor.
Uses
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
Uses
Antineoplastic.
Uses
Antineoplastic;DNA replication inhibitor
Definition
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.
brand name
Matulane (Sigma-Tau).
General Description
White to pale yellow crystalline powder with a slight odor. Acid to litmus.
General Description
Procarbazine is available in 50-mg tablets for oral administrationin the treatment of Hodgkin’s (part of MOPP) andnon-Hodgkin’s disease, brain cancer, and mycosis fungoides.The major mechanisms of resistance appear to beenhanced activity of DNA-repair enzymes including enhancedO-6-alkylguanine DNA transferase (AGAT),which removes the methyl group from the O-6 of guanine.The agent is rapidly and completely absorbed after oral administrationand extensively metabolized in the liver togive azo-procarbazine followed by further oxidation tomethyldiazine and the aldehyde. The parent drug andmetabolites cross the blood-brain barrier. Elimination occursin the urine mostly as metabolites with an eliminationhalf-life of 1 hour. Myelosuppression is dose limiting, generallypresenting as thrombocytopenia that may be followedby leucopenia. Glucose-6-phosphate dehydrogenasedeficient patients may develop hemolytic anemia duringprocarbazine therapy. Other adverse effects include nausea,vomiting, hypersensitivity, flulike symptoms, amenorrhea,and azoospermia. Central nervous symptom effectsmay be seen, including lethargy, confusion, neuropathies,and seizure.
Air & Water Reactions
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reactivity Profile
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
Fire Hazard
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.
Potential Exposure
Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.
Veterinary Drugs and Treatments
In veterinary medicine, procarbazine is used as part of MOPP protocols (mechlorethamine, vincristine, procarbazine, prednisone) to treat lymphomas in dogs and cats. It may be of benefit in treating granulomatous meningoencephalitis (GME) in dogs.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Procarbazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Procarbazine hydrochloride manufacturers
- Product
- Procarbazine hydrochloride 366-70-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-07
- Product
- Procarbazine hydrochloride 366-70-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-06-28
- Product
- Procarbazine Hydrochloride 366-70-1
- Price
- US $1000.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 99 %
- Supply Ability
- 10000kg
- Release date
- 2021-06-25