8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- Product Name
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- CAS No.
- 51116-01-9
- Chemical Name
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- Synonyms
- BR-CGMP, NA;8-BR-CGMP NA;8-BROMO-CGMP NA;Einecs 256-993-8;8-BROMO-CGMP SODIUM;8-BR-CGMP SODIUM SALT;(115974-70-4) 8-AET-cGMP;8-BROMO-CGMP, SODIUM SALT;8-bromo-Cyclic GMP (sodium salt);8 Bromo cGMP sodium,8BromocGMP sodium
- CBNumber
- CB6687726
- Molecular Formula
- C10H12BrN5NaO7P
- Formula Weight
- 448.1
- MOL File
- 51116-01-9.mol
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Property
- storage temp.
- -20°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- Water Solubility
- Soluble to 100 mM in water
Safety
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- B1381
- Product name
- 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $89.4
- Updated
- 2024/03/01
- Product number
- 203820
- Product name
- Guanosine 3?,5?-cyclic Monophosphate, 8-Bromo-, Sodium Salt
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 15992
- Product name
- 8-bromo-Cyclic GMP (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 15992
- Product name
- 8-bromo-Cyclic GMP (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- B1381
- Product name
- 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $179
- Updated
- 2024/03/01
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Chemical Properties,Usage,Production
Description
8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Chemical Properties
White powder
Uses
8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Definition
ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).
Biological Activity
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .
storage
Desiccate at -20°C