N-Benzylpiperidine-4-carboxaldehyde

Synthesis

Product Name: N-Benzylpiperidine-4-carboxaldehyde
CAS No.: 22065-85-6
Chemical Name: N-Benzylpiperidine-4-carboxaldehyde
Synonyms: Benzylpiperidine-4-carboxaldehyde;1-Benzylpiperidine-4-carboxaldehyde;N-Benzyl-4-Piperidinecarboxaldehyde95%;N-Benzylpiperidine-4-carboxaldehyde 95%;1-(Phenylmethyl)-4-piperidinecarbaldehyde;1-(Phenylmethyl)-4-piperidinecarboxaldehyde;1-Benzyl-4-piperidinecarboxaldehyde,1-Benzyl-4-formylpiperidine;1-Benzyl-4-formylpiperidine, [(4-Formylpiperidin-1-yl)methyl]benzene;ZERO/005913;RSYY（Avanafil)-1
CBNumber: CB6703107
Molecular Formula: C13H17NO
Formula Weight: 203.28
MOL File: 22065-85-6.mol

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N-Benzylpiperidine-4-carboxaldehyde Property

Melting point:: 145-149 °C
Boiling point:: 315.4 °C/760 mmHg
Density: 1.026 g/mL at 25 °C
refractive index: n20/D 1.537
Flash point:: >230 °F
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Acetone (Slightly), Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Sli
form: Liquid
pka: 8.04±0.10(Predicted)
color: Clear colorless to pale yellow
Sensitive: Air Sensitive
InChIKey: SGIBOXBBPQRZDM-UHFFFAOYSA-N
CAS DataBase Reference: 22065-85-6(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-41
Safety Statements: 26-28-36/37/39
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 664081
Product name: N-Benzylpiperidine-4-carboxaldehyde
Purity: 95%
Packaging: 1g
Price: $67.4
Updated: 2023/06/20

Sigma-Aldrich

Product number: 664081
Product name: N-Benzylpiperidine-4-carboxaldehyde
Purity: 95%
Packaging: 5g
Price: $271
Updated: 2023/06/20

TCI Chemical

Product number: B3190
Product name: 1-Benzyl-4-piperidinecarboxaldehyde
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $65
Updated: 2024/03/01

TCI Chemical

Product number: B3190
Product name: 1-Benzyl-4-piperidinecarboxaldehyde
Purity: >96.0%(GC)(T)
Packaging: 25g
Price: $209
Updated: 2024/03/01

TRC

Product number: B288620
Product name: 1-Benzyl-4-piperidine-carboxaldehyde
Packaging: 25g
Price: $540
Updated: 2021/12/16

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N-Benzylpiperidine-4-carboxaldehyde Chemical Properties,Usage,Production

Synthesis

A round bottom flask was charged with oxalyl chloride (16.2 g, 0.12 mol), dichloromethane (150 mL) and anhydrous dimethyl sulfoxide (20 mL). Stir the reaction mixture mass in a cryo bath at -70 °C for 15 min. The resulting mixture is charged dropwise with N-benzyl piperidine alcohol 3 (20 g, 0.097 mol), along with triethylamine (24.6 g, 0.24 mol) and continued stirring for the next 15 min. After that, the mass is allowed to attain room temperature overnight, then diluted with dichloromethane (100 mL) and quenched with cold water. The organic layer was washed subsequently with 5 % HCl solution, brine solution, 5 % sodium bicarbonate solution and dried over sodium sulfate. Toluene was removed in vacuo to afford N-Benzylpiperidine-4-carboxaldehyde (19.2 g, 96 %).

Chemical Properties

Colorless Oil

Uses

Reactant for:

Stereospecific allylic alkylation
Reactions of Grignard reagents with carbonyl compounds
Fluorodenitrations and nitrodehalogenations for labeled PET ligands and fluoropharmaceuticals
Selective α1 receptor antagonists

Reactant for synthesis of:

Donepezil
MCH-R1 antagonists

N-Benzylpiperidine-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzylpiperidine-4-carboxaldehyde Suppliers

Americas 1 Canada 2 China 221 Europe 3 France 1 Germany 2 India 73 Japan 2 Russia 1 South Korea 1 Switzerland 3 United Kingdom 12 United States 46 Global 368

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View Lastest Price from N-Benzylpiperidine-4-carboxaldehyde manufacturers

Hebei Duling International Trade Co. LTD

Product: N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-02-22

Henan Aochuang Chemical Co.,Ltd.

Product: N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Qiuxian Baitai New Material Co., LTD

Product: N-Benzylpiperidine-4-carboxaldehyde 22065-85-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500ton/Month
Release date: 2021-12-21

22065-85-6, N-Benzylpiperidine-4-carboxaldehydeRelated Search:

Benzyl chloride DROPERIDOL N-Benzyl-4-piperidone Benzyltrimethylammonium chloride Benzyltriethylammonium chloride Haloperidol Ethyl 1-benzylpiperidine-4-carboxylate Phenylacetone Diphenoxylate 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride 4-Anilino-1-benzyl-4-piperidinecarboxylic acid 1-BENZOYLPIPERIDINE-4-CARBOXYLIC ACID Ethyl1-(4-Bromo-benzyl)-piperidine-4-carboxylate N-BENZYL-4-AMINO-PIPERIDINE-4-CARBOXAMIDE 1-benzyl-4-phenylpiperidine-4-carboxylic acid

1-(Phenylmethyl)-4-piperidinecarbaldehyde

1-Benzyl-4-piperidinecarboxaldehyde,1-Benzyl-4-formylpiperidine

N-Benzylpiperidine-4-carboxyaldehyde

N-Benzy-4-Piperidine Carboxaldehyde

1-Benzyl-4-formylpiperidine, [(4-Formylpiperidin-1-yl)methyl]benzene

1-Benzylisonipecotaldehyde

N-Benzylpiperidine-4-carboxaldehyde 95%

N-BENZYLPIPERIDINE-4-CARBOXALDEHYDE

1-BENZYL-PIPERIDINE-4-CARBALDEHYDE

Donepezil Impurity 40

1-Benzylpiperidine-4-carboxaldehyde 95%

N-benzyl piperdine aldehyde

1-BENZYL-4-PIPERIDINECARBALDEHYDE

1-BENZYL-4-PIPERIDINECARBOXALDEHYDE

N-Benzyl-4-Formyl Piperidine

1-Benzy-4-Piperidine Carboxyaldehyde

1-Benzyl-4-Formyl Piperidine

1-Benzy-4-Piperidine Carboxaldehyde

1-benzy-4-piperidine arboxyaldehyde

1-Benzyl-4-PiperidineCarboxyaldehyde

N-Benzyl-4-Piperidinecarboxaldehyde95%

1-BENZYLPIPERIDINE-4-CARBALDEHYDE 96%

1-(Phenylmethyl)-4-piperidinecarboxaldehyde

4-Formyl-1-benzylpiperidine

N-(Phenylmethyl)piperidine-4-carboxaldehyde

N-Benzyl-4-formylpiperidin

1-Benzylpiperidine-4-carboxaldehyde

4-PIPERIDINECARBOXALDEHYDE,1-(PHENYLMETHYL)

N‐Benzylisonipecotinaldehyde

ZERO/005913

1-Benzyl-4-piperidinecarboxaldehyde &gt

N-Benzylpiperidine-4-carbaldehyde

-Benzylpiperidine-4-carboxaldehyde

1-benzyl -4-piperdine aldehyde

Benzylpiperidine-4-carboxaldehyde

RSYY（Avanafil)-1

N-Benzylpiperdine carboxaldehyde

1-BENZYL 4 PIPERDINE CARBOXALDEHYDE

1-Benzylpiperidine-4-Carboxaldehyde (BPCA)

22065-85-6

2065-85-6

2447-57-7

Building Blocks

Piperidines

Heterocyclic Building Blocks

pharmacetical

Alcohol Aldehyde & acid series

Piperidine

(intermediate of donepezil)

Aromatics

Heterocycles

Building Blocks

Heterocyclic Building Blocks

Piperidines