SULBENICILLIN

Product Name: SULBENICILLIN
CAS No.: 41744-40-5
Chemical Name: SULBENICILLIN
Synonyms: SBPC;Kedacillina;Subenicillin;SULBENICILLIN;Sulbenicilina;(R)-Sulbenicillin;D-(-)-Sulbenicillin;Sulbenicillin, D-(-)-;a-Sulfobenzylpenicillin;SULBENICILLIN USP/EP/BP
CBNumber: CB6715306
Molecular Formula: C16H18N2O7S2
Formula Weight: 414.45
MOL File: 41744-40-5.mol

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SULBENICILLIN Property

Melting point:: 197 °C (decomp)
Density: 1?+-.0.1 g/cm3(Predicted)
pka: 0.28±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013659
Product name: SULBENICILLIN
Purity: 98.00%
Packaging: 1G
Price: $1709.4
Updated: 2021/12/16

AvaChem

Product number: 2843
Product name: Sulbenicillin
Packaging: 10mg
Price: $39
Updated: 2021/12/16

AvaChem

Product number: 2843
Product name: Sulbenicillin
Packaging: 25mg
Price: $59
Updated: 2021/12/16

AvaChem

Product number: 2843
Product name: Sulbenicillin
Packaging: 100mg
Price: $129
Updated: 2021/12/16

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SULBENICILLIN Chemical Properties,Usage,Production

Originator

Lillacillin,Takeda,Japan,1973

Definition

ChEBI: A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.

Manufacturing Process

To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.

Therapeutic Function

Antibacterial

Antimicrobial activity

α-Sulfobenzylpenicillin, a semisynthetic penicillin supplied as the disodium salt. Its antimicrobial spectrum and pharmacokinetic pharmacokinetic behavior closely resemble those of carbenicillin. Following intravenous administration of 4 g, the mean plasma concentration at 1 h was approximately 160 mg/L, with a plasma elimination half-life of around 70 min. It is largely excreted in the urine, about 80% of the dose appearing in the first 24 h, less than 5% as the penicilloic acid. It has been noted that the penicilloic acid causes much stronger platelet aggregation than its parent. It is of very limited availability.

SULBENICILLIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SULBENICILLIN Suppliers

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View Lastest Price from SULBENICILLIN manufacturers

Career Henan Chemical Co

Product: SULBENICILLIN 41744-40-5
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

41744-40-5, SULBENICILLINRelated Search:

Cefixime Furbenicillin Oxiracetam Aztreonam Omeprazole Thymopentin Amoxicillin PotassiuM sodiuM Dehydroandrographolide Succinate Ambroxol Cefoxitin Cephalosporin SULBENICILLIN DISODIUM SALT,SULBENICILLIN SODIUM ACES SULBENICILLIN D(-)- A -SULFOPHENYLACETYL ACID (D-SPA, FOR SULBENICILLIN SODIUM ) Sulbenicillin toluene-alpha-sulphonic acid DL-SULFOPHENYL ACETIC ACID (DL-SPA, FOR SULBENICILLIN SODIUM )

SULBENICILLIN

Subenicillin

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, [2S-[2a,5a,6b(S*)]]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2R)-phenylsulfoacetyl]amino]-, (2S,5R,6R)- (9CI)

a-Sulfobenzylpenicillin

D-(-)-Sulbenicillin

SBPC

Sulbenicillin, D-(-)-

(2S,5β)-3,3-Dimethyl-7-oxo-6α-[[(R)-phenyl(sulfo)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid

(R)-Sulbenicillin

6α-[(R)-Phenyl(sulfo)acetylamino]penicillanic acid

(2S,5R,6R)-6-((S)-Carbamoyl(phenyl)methanesulfonoyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfoacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfo-ethanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenyl-2-sulfo-acetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-, (2S,5R,6R)-

SULBENICILLIN USP/EP/BP

Kedacillina

Sulbenicilina

41744-40-5