7-Nitro-1-tetralone

Application

Product Name: 7-Nitro-1-tetralone
CAS No.: 40353-34-2
Chemical Name: 7-Nitro-1-tetralone
Synonyms: 7-NITROTETRALONE;7-NITRO-3,4-DIHYDR;7-NITRO-1-TETRALONE;7-NITROTETRA-1-LONE;7-nitro-1-tetrralone;7-Nitrotetralin-1-one;7-Nitrotetra-1-lone 98%;7-Nitro-1-tetralone,97%;3,4-dihydro-7-nitro-1(2h)-naphthalenon;7-NITRO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
CBNumber: CB6715669
Molecular Formula: C10H9NO3
Formula Weight: 191.18
MOL File: 40353-34-2.mol

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7-Nitro-1-tetralone Property

Melting point:: 108-109°C
Boiling point:: 349.1±31.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Orange to Green
BRN: 1570515
CAS DataBase Reference: 40353-34-2(CAS DataBase Reference)
NIST Chemistry Reference: 1(2H)-naphthalenone, 3,4-dihydro-7-nitro-(40353-34-2)

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Safety

Hazard Codes: Xn
Risk Statements: 22-52
Safety Statements: 22-24/25
RTECS: QK5025000
HS Code: 2914790090
Toxicity: mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00954,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0945
Product name: 7-Nitro-1-tetralone
Purity: >98.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: N0945
Product name: 7-Nitro-1-tetralone
Purity: >98.0%(GC)
Packaging: 5g
Price: $115
Updated: 2025/07/31

TRC

Product number: N565193
Product name: 7-Nitro-1-tetralone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 5420AB
Product name: 7-Nitro-3,4-dihydronaphthalen-1(2H)-one
Packaging: 250mg
Price: $74
Updated: 2021/12/16

AK Scientific

Product number: 5420AB
Product name: 7-Nitro-3,4-dihydronaphthalen-1(2H)-one
Packaging: 1g
Price: $84
Updated: 2021/12/16

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7-Nitro-1-tetralone Chemical Properties,Usage,Production

Application

7-Nitro-3,4-Dihydro-2H-1-naphthone is a ketone derivative that can be used as a pharmaceutical intermediate.

Chemical Properties

earthy yellow powder

Synthesis

529-34-0

40353-34-2

General procedure for the synthesis of 7-nitro-3,4-dihydro-2H-1-naphthalenone from 1-tetralone: Concentrated sulfuric acid (60 mL) was cooled to 0 °C in an ice bath. 1-Tetrahydronaphthalenone (8 g, 54.7 mmol) was added with stirring, and then potassium nitrate (6 g, 59.3 mmol, 1.08 eq.) dissolved in concentrated sulfuric acid (18 mL) was slowly added dropwise through a dropping funnel, controlling the reaction temperature to no more than 15 °C. The reaction was carried out at a controlled temperature of 15 °C. The reaction was completed with the addition of potassium nitrate (6 g, 59.3 mmol, 1.08 eq.). After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour. The reaction was quenched by pouring the reaction solution into crushed ice, the precipitate was collected by filtration and washed with distilled water. After drying, recrystallization was carried out through a solvent mixture of ethanol/water (1:1) to give 7-nitro-3,4-dihydro-2H-1-naphthalenone (8.5 g, 81% yield) as a light yellow solid with a melting point of 104-106 °C. The product was analyzed by infrared spectroscopy (IR, film) showing characteristic absorption peaks located at 1675 cm?1, 1500 cm?1 and 1340 cm?1. The nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) data are as follows: δ 2.18-2.25 (2H, m, CH2), 2.75 (2H, t, J = 6.8 Hz, CH2), and 3.10 (2H, t, J = 6.1 Hz, CH2), 7.45 (1H, d, J = 8.4 Hz, ArH), 8.30 (1H, dd, J = 2.4 Hz, 8.4 Hz, ArH), 8.86 (1H, d, J = 2.4 Hz, ArH).

References

[1] Patent: WO2004/87124, 2004, A1. Location in patent: Page/Page column 47-48
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 237 - 249
[3] Tetrahedron Letters, 1994, vol. 35, # 38, p. 7061 - 7064
[4] Justus Liebigs Annalen der Chemie, 1927, vol. 451, p. 53
[5] Journal of the Chemical Society. Perkin transactions 1, 1969, vol. 10, p. 1376 - 1378

7-Nitro-1-tetralone Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Nitro-1-tetralone Suppliers

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View Lastest Price from 7-Nitro-1-tetralone manufacturers

Shanghai Rlavie Technology Co ltd

Product: 7-Nitro-1-tetralone 40353-34-2
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-17

Career Henan Chemical Co

Product: 7-Nitro-1-tetralone 40353-34-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

40353-34-2, 7-Nitro-1-tetraloneRelated Search:

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40353-34-2