ChemicalBook > CAS DataBase List > Prednisone

Prednisone

Product Name
Prednisone
CAS No.
53-03-2
Chemical Name
Prednisone
Synonyms
Deltasone;MOPP;PREDNISON;Prednisone Micronised;Cortan;Orasone;Paracort;Bicortone;Servisone;Prednicen-M
CBNumber
CB6716222
Molecular Formula
C21H26O5
Formula Weight
358.43
MOL File
53-03-2.mol
More
Less

Prednisone Property

Melting point:
236-238 °C(lit.)
alpha 
169 º (c=0.5, dioxane)
Boiling point:
410.86°C (rough estimate)
Density 
1.1121 (rough estimate)
refractive index 
170 ° (C=0.5, Dioxane)
Flash point:
>200℃
storage temp. 
2-8°C
solubility 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka
12.36±0.60(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
115mg/L(25 ºC)
Merck 
7722
BRN 
2065301
BCS Class
1?
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
53-03-2(CAS DataBase Reference)
NIST Chemistry Reference
Prednisone(53-03-2)
IARC
3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System
Prednisone (53-03-2)
More
Less

Safety

Hazard Codes 
Xn
Safety Statements 
36/37/39-45-26-16
Hazardous Substances Data
53-03-2(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P6254
Product name
Prednisone
Purity
≥98%
Packaging
1G
Price
$43
Updated
2023/06/20
Sigma-Aldrich
Product number
P6254
Product name
Prednisone
Purity
≥98%
Packaging
5G
Price
$157
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0001921
Product name
Prednisone for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001921
Price
$215
Updated
2023/06/20
Sigma-Aldrich
Product number
P6254
Product name
Prednisone
Purity
≥98%
Packaging
10G
Price
$279
Updated
2023/06/20
Sigma-Aldrich
Product number
P6254
Product name
Prednisone
Purity
≥98%
Packaging
25G
Price
$537
Updated
2023/06/20
More
Less

Prednisone Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

Uses

Downregulates TNF-α production and NF-κB expression

Uses

Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.

Indications

Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.

Definition

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

brand name

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

General Description

Odorless white crystalline powder.

General Description

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

Air & Water Reactions

Very slightly water soluble .

Hazard

Questionable carcinogen.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

Synthesis

Prednisone is 17|á,21-dihydroxypregna-1,4-dien-3,11-20-trione (27.1.31). Prednisone differs from cortisone in the presence of an additional double bond between C1 and C2. There are various ways of synthesizing it. In one of these, as is in the case when synthesizing cortisone, it is synthesized from dihydrocortisone acetate. However, in the given example, this compound undergoes dibromination by molecular bromine, giving 2,4-dibromo-derivative of dihydrocortisone 27.1.30. Dehydrobromination with 3,5-lutidine, followed by subsequent hydrolysis of the acetyl group using potassium bicarbonate gives the desired prednisone (27.1.31). Prednisone is also synthesized by microbiological dehydrogenation of cortisone.

Purification Methods

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

Prednisone Preparation Products And Raw materials

Raw materials

Selenium dioxide Cortisone acetate Hydrocortisone

Preparation Products

Deprodone propionate
More
Less

Prednisone Suppliers

Australia 1 Belgium 2 Brazil 3 Canada 3 China 314 Egypt 1 Europe 2 France 7 Germany 14 India 25 Indonesia 1 Italy 1 Japan 3 Jordan 1 Mexico 1 Poland 1 Russia 1 Singapore 1 South Korea 2 Spain 2 Switzerland 2 The Netherlands 3 Ukraine 1 United Kingdom 10 United States 58 Global 460
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Lalilab, Inc
Tel
--
Fax
--
Email
info@lalilab.com
Country
United States
ProdList
69
Advantage
58
American International Chemical LLC - (AIC LLC)
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
53
Advantage
58
IsoSciences
Tel
--
Fax
--
Email
info@isosciences.com
Country
United States
ProdList
379
Advantage
58
Albany Molecular Research Inc. (AMRI)
Tel
--
Fax
--
Email
Customerservice@amriglobal.com
Country
United States
ProdList
61
Advantage
58
Camphor Technologies Inc.
Tel
--
Fax
--
Country
United States
ProdList
148
Advantage
58
ZETA Pharmaceuticals, L.L.C.
Tel
--
Fax
--
Email
zeta@zetapharm.com
Country
United States
ProdList
102
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
ACIC Fine Chemicals Inc.
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
492
Advantage
48
Chemceed Corportaion
Tel
--
Fax
--
Email
inquiry@chemceed.com
Country
United States
ProdList
175
Advantage
50
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
American International Chemical, Inc.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
531
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
SANOFI CHIMIE
Tel
--
Fax
--
Email
johnd@sanofi.com
Country
United States
ProdList
34
Advantage
58
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
794
Advantage
76
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@par-chem.com
Country
United States
ProdList
740
Advantage
66
Pfizer Inc. - Pfizer CentreSource
Tel
--
Fax
--
Country
United States
ProdList
18
Advantage
62
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Lab Express
Tel
--
Fax
--
Email
sales@labexpress.com
Country
United States
ProdList
1577
Advantage
67
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from Prednisone manufacturers

CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD.
Product
Prednisone 53-03-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20
Release date
2025-03-12
Baoji Guokang Bio-Technology Co., Ltd.
Product
Prednisone 53-03-2
Price
US $800.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2021-06-07
Hebei Mujin Biotechnology Co.,Ltd
Product
Prednisone 53-03-2
Price
US $0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20ton
Release date
2021-06-03

53-03-2, PrednisoneRelated Search:

Hydrocortisone-17-butyrate CORTISONE Prednisolone Fludrocortisone PREDNISONE SODIUM PHOSPHATE Hydrocortisone sodium succinate Prednisolone sodium succinate prednisone 21-acetate,PREDNISONE ACETATE Hydrocortisone Dexamethasone-17-acetate 6alpha-Methylprednisolone sodium succinate Methylprednisolone acetate Prednisolone-21-acetate Methylprednisolone PREDNISONE HEMISUCCINATE:HISTAMINE chloroprednisone 21-acetate PREDNISONE 21-HEMISUCCINATE,PREDNISONE HEMISUCCINATE Pregna-1,4-diene-3,11,20-trione, 17-hydroxy-21-(phosphonooxy)-, disodium salt Prednisone Tablets

  • 1,2-Dehydrocortisone
  • 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
  • 11,20-trione,17,21-dihydroxy-pregna-4-diene-3
  • 11,20-trione,17,21-hydroxy-pregna-4-diene-3
  • Ancortone
  • Bicortone
  • Colisone
  • Cortan
  • Cortancyl
  • Cortidelt
  • delta-E
  • Deltasone
  • delta-sone
  • Deltison
  • Deltisone
  • Deltra
  • Di-Adreson
  • Encorton
  • Encortone
  • Enkorton
  • Hostacortin
  • In-Sone
  • Juvason
  • Lisacort
  • meburamide
  • Metacortandracin
  • Meticorten
  • NCI-C04897
  • nci-co4897
  • NSC 10023
  • nsc10023
  • Orasone
  • Paracort
  • Precort
  • Prednicen-M
  • Prednilonga
  • Prednizon
  • 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE
  • PREDNISONE, PH EUR
  • Prednisone,98%
  • 1,4-Pregnadiene-17a,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • 1,4-pregnadiene-17α,21-diol-3,11,20-trione
  • PREDNISONE,ANHYDROUS,MICRONIZED,USP
  • PREDNISONE,ANHYDROUS,POWDER,USP
  • MOPP
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone, Prednisonum
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
  • Apo-Prednisone
  • Ancotone
  • 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
  • Prednisolone EP Impurity B
  • Prednisolone Impurity 2（Prednisolone EP Impurity B）
  • Cotone
  • Dacortin
  • Decortancyl
  • Decortin