ChemicalBook > CAS DataBase List > 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

Product Name
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
CAS No.
84477-87-2
Chemical Name
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
Synonyms
H-7;H-72HCl;H-7 inhibitor;Protein kinase inhibitor H-7;1-(5-Isoquinolylsulfonyl)-2-methylpiperazine;1-(5-isoquinolinesulfonyl)-2-methylpiperazine;Isoquinoline-5-sulfonic 2-methyl-1-piperazide;5-(2-methylpiperazine-1-sulfonyl)isoquinoline;5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
CBNumber
CB6719627
Molecular Formula
C14H17N3O2S
Formula Weight
291.37
MOL File
84477-87-2.mol
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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Property

Boiling point:
495.3±55.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethanol: 20 mg/mL
pka
7.69±0.40(Predicted)
form 
Solid
color 
White to light yellow
BRN 
5482740
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Safety

WGK Germany 
3
RTECS 
TL9305000
10
Toxicity
LD50 intravenous in mouse: 94mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6891
Product name
H-7
Packaging
25mg
Price
$1060
Updated
2024/03/01
Sigma-Aldrich
Product number
I6891
Product name
H-7
Packaging
5mg
Price
$324
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
KIN0000366
Product name
H-7
Purity
95.00%
Packaging
10MG
Price
$653.68
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000366
Product name
H-7
Purity
95.00%
Packaging
50MG
Price
$1012.65
Updated
2021/12/16
Chemenu
Product number
CM229708
Product name
5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline
Purity
97%
Packaging
1g
Price
$729
Updated
2021/12/16
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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Chemical Properties,Usage,Production

Definition

ChEBI: A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Biological Activity

Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively.

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
1005
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
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58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29902
Advantage
58

84477-87-2, 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINERelated Search:


  • 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
  • 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
  • 1-(5-isoquinolinylsulfonyl)-2-*methylpiperazine F
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-*METHYLPIP ERAZINE FRE
  • H-72HCl
  • 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide
  • (Isoquinoline-5-yl)(2-methylpiperazine-1-yl) sulfone
  • 1-(5-Isoquinolylsulfonyl)-2-methylpiperazine
  • 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
  • Isoquinoline-5-sulfonic 2-methyl-1-piperazide
  • 5-[(2-methyl-1-piperazinyl)sulfonyl]Isoquinoline
  • 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
  • H-7
  • Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-
  • Protein kinase inhibitor H-7
  • H-7 inhibitor
  • 84477-87-2
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Protein kinase A and protein kinase C (PKA and PKC)
  • Serine/Threonine Kinase Inhibitors