ChemicalBook > CAS DataBase List > 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

Product Name
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
CAS No.
84477-87-2
Chemical Name
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
Synonyms
H-7;H-72HCl;H-7 inhibitor;Protein kinase inhibitor H-7;1-(5-Isoquinolylsulfonyl)-2-methylpiperazine;1-(5-isoquinolinesulfonyl)-2-methylpiperazine;Isoquinoline-5-sulfonic 2-methyl-1-piperazide;5-(2-methylpiperazine-1-sulfonyl)isoquinoline;5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
CBNumber
CB6719627
Molecular Formula
C14H17N3O2S
Formula Weight
291.37
MOL File
84477-87-2.mol
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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Property

Boiling point:
495.3±55.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethanol: 20 mg/mL
pka
7.69±0.40(Predicted)
form 
Solid
color 
White to light yellow
BRN 
5482740
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Safety

WGK Germany 
3
RTECS 
TL9305000
F 
10
Toxicity
LD50 intravenous in mouse: 94mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6891
Product name
H-7
Packaging
25mg
Price
$1060
Updated
2024/03/01
Sigma-Aldrich
Product number
I6891
Product name
H-7
Packaging
5mg
Price
$324
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
KIN0000366
Product name
H-7
Purity
95.00%
Packaging
10MG
Price
$653.68
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000366
Product name
H-7
Purity
95.00%
Packaging
50MG
Price
$1012.65
Updated
2021/12/16
Chemenu
Product number
CM229708
Product name
5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline
Purity
97%
Packaging
1g
Price
$729
Updated
2021/12/16
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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Chemical Properties,Usage,Production

Definition

ChEBI: A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Biological Activity

Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively.

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Suppliers

China 31 Germany 1 South Korea 1 Switzerland 2 United Kingdom 1 United States 11 Global 47
SIGMA-RBI
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Switzerland
ProdList
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AXXORA, LLC
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alexis-ch@alexis-corp.com
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Switzerland
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84477-87-2, 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINERelated Search:

1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE 1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE DIHYDROCHLORIDE 1-METHANESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE 1-BENZENESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE (S)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

  • 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
  • 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
  • 1-(5-isoquinolinylsulfonyl)-2-*methylpiperazine F
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-*METHYLPIP ERAZINE FRE
  • H-72HCl
  • 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide
  • (Isoquinoline-5-yl)(2-methylpiperazine-1-yl) sulfone
  • 1-(5-Isoquinolylsulfonyl)-2-methylpiperazine
  • 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
  • Isoquinoline-5-sulfonic 2-methyl-1-piperazide
  • 5-[(2-methyl-1-piperazinyl)sulfonyl]Isoquinoline
  • 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
  • H-7
  • Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-
  • Protein kinase inhibitor H-7
  • H-7 inhibitor
  • 84477-87-2
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Protein kinase A and protein kinase C (PKA and PKC)
  • Serine/Threonine Kinase Inhibitors