1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

Product Name: 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
CAS No.: 84477-87-2
Chemical Name: 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
Synonyms: H-7;H-72HCl;H-7 inhibitor;Protein kinase inhibitor H-7;1-(5-Isoquinolylsulfonyl)-2-methylpiperazine;1-(5-isoquinolinesulfonyl)-2-methylpiperazine;Isoquinoline-5-sulfonic 2-methyl-1-piperazide;5-(2-methylpiperazine-1-sulfonyl)isoquinoline;5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
CBNumber: CB6719627
Molecular Formula: C14H17N3O2S
Formula Weight: 291.37
MOL File: 84477-87-2.mol

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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Property

Boiling point:: 495.3±55.0 °C(Predicted)
Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ethanol: 20 mg/mL
pka: 7.69±0.40(Predicted)
form: Solid
color: White to light yellow
BRN: 5482740

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Safety

WGK Germany: 3
RTECS: TL9305000
F: 10
Toxicity: LD50 intravenous in mouse: 94mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I6891
Product name: H-7
Packaging: 25mg
Price: $1060
Updated: 2024/03/01

Sigma-Aldrich

Product number: I6891
Product name: H-7
Packaging: 5mg
Price: $324
Updated: 2023/06/20

American Custom Chemicals Corporation

Product number: KIN0000366
Product name: H-7
Purity: 95.00%
Packaging: 10MG
Price: $653.68
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000366
Product name: H-7
Purity: 95.00%
Packaging: 50MG
Price: $1012.65
Updated: 2021/12/16

Chemenu

Product number: CM229708
Product name: 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline
Purity: 97%
Packaging: 1g
Price: $729
Updated: 2021/12/16

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1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Chemical Properties,Usage,Production

Definition

ChEBI: A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Biological Activity

Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively.

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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84477-87-2, 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINERelated Search:

1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE 1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE DIHYDROCHLORIDE 1-METHANESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE 1-BENZENESULFONYL-PIPERAZINE 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE (S)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE (R)-4-(Isoquinoline-5-sulfonyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester dihydrochloride

1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin

1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE

1-(5-isoquinolinylsulfonyl)-2-*methylpiperazine F

1-(5-ISOQUINOLINYLSULFONYL)-2-*METHYLPIP ERAZINE FRE

H-72HCl

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide

(Isoquinoline-5-yl)(2-methylpiperazine-1-yl) sulfone

1-(5-Isoquinolylsulfonyl)-2-methylpiperazine

5-(2-methylpiperazin-1-yl)sulfonylisoquinoline

Isoquinoline-5-sulfonic 2-methyl-1-piperazide

5-[(2-methyl-1-piperazinyl)sulfonyl]Isoquinoline

5-(2-methylpiperazine-1-sulfonyl)isoquinoline

H-7

Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-

Protein kinase inhibitor H-7

H-7 inhibitor

84477-87-2

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Kinase/Phosphatase Biology

Protein kinase A and protein kinase C (PKA and PKC)

Serine/Threonine Kinase Inhibitors