Physical and Chemical Properties Rhubarb
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Aloe emodin

Physical and Chemical Properties Rhubarb
Product Name
Aloe emodin
CAS No.
481-72-1
Chemical Name
Aloe emodin
Synonyms
ALOE-EMODIN;RHA;Diacerein IMpurity B;1,8-Dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione;Diacerein impurity B CRS;1,8-DIHYDROXY-3-(HYDROXYMETHYL)ANTHRAQUINONE;1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9,10-ANTHRACENEDIONE;C:C&B63;NSC 38628;Aloe-eModol
CBNumber
CB6727767
Molecular Formula
C15H10O5
Formula Weight
270.24
MOL File
481-72-1.mol
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Aloe emodin Property

Melting point:
223-224°C
Boiling point:
373.35°C (rough estimate)
Density 
1.3280 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka
6.30±0.20(Predicted)
form 
Solid
color 
Orange to Dark Orange
Merck 
14,306
BRN 
2059062
Stability:
Hygroscopic
InChIKey
YDQWDHRMZQUTBA-UHFFFAOYSA-N
LogP
3.254 (est)
CAS DataBase Reference
481-72-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CB6712200
F 
10
HS Code 
29146990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7687
Product name
Aloe Emodin
Purity
≥95% (HPLC)
Packaging
25mg
Price
$1010
Updated
2024/03/01
Sigma-Aldrich
Product number
93938
Product name
Aloe Emodin
Purity
analytical standard
Packaging
10mg
Price
$411
Updated
2024/03/01
TCI Chemical
Product number
A2491
Product name
Aloe Emodin
Purity
>97.0%(HPLC)
Packaging
1g
Price
$741
Updated
2024/03/01
TCI Chemical
Product number
A2491
Product name
Aloe Emodin
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$185
Updated
2024/03/01
Cayman Chemical
Product number
11677
Product name
Aloe Emodin
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
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Aloe emodin Chemical Properties,Usage,Production

Physical and Chemical Properties

Aloe emodin aloe is one the major components of the aloe essential oils. It is either presented in aloe in the free form or presented in rhubarb, senna, and aloe in the form of glycosides. The compound precipitated from toluene or ethanol is yellow-orange needles with a relative molecular mass of 270.25 and the melting point of 223~224 ℃. It can be subject to sublimation in the carbon dioxide gas stream. It is easily soluble in hot ethanol, ether, benzene, with the solution exhibiting yellow color. It is also soluble in aqueous ammonia and sulfuric acid with the solution exhibiting crimson color.
The main active ingredient of aloe is the barbaloin and aloe emodin. The aloe juice has anti-inflammatory effect and can promote healing of skin damage.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Rhubarb

Rhubarb is a kind of commonly used traditional Chinese medicine. It was initially recorded in the "Shen Nong's Herbal Classic", low-grade product. It is recorded in every generations of Ancient herbal medicine. Rhubarb is the Polygonaceae plant rhubarb Rheum, Rheum tanguticum and the dried roots or rhizomes of medicinal rhubarb Rheum officinale Baill. It is mainly produced in Sichuan, Gansu, Qinghai and other places. Rhubarb has effects such as purge heating and intestine cleaning, blood cooling and detoxification effect, and blood stasis dredging and can be applied to the treatment of the internal heating and constipation, Indigestion, abdominal pain, diarrhea, heat jaundice, vomiting blood, red eyes, swollen throat, abdominal pain, appendicitis, carbuncle swollen boils, blood stasis amenorrhea, and bruises. It can also be applied to external treatment of fire burns, upper gastrointestinal bleeding and so on. We can apply it with raw use or wine-processing, wine steaming or fried carbon.
Rhubarb has inhibitory effect on most Gram-positive bacteria as well as some Gram-negative bacteria in vitro. Its main active ingredient is anthraquinone derivative with the aloe emodin, emodin and rhein yielding the best efficacy.
It has inhibition on the murine leukemia P388: people extracted rhein, emodin and aloe emodin from rhubarb. These three kinds of anthraquinone can all reduce the number of cancer cells and the amount of ascites in tumor mice with different extent, in which the effect of rhein is the most significant and the effect of aloe emodin is relatively poor; the effect is generally correlated with the prolonged survival period. Emodin, rhein has a strong inhibitory effect on the biosynthesis of DNA, RNA and protein while aloe emodin strong has a weak inhibitory effect.

Figure 1 Rheum officinale Baill.

Chemical Properties

Orange Solid

Uses

Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).

Uses

Aloe-emodin may be used as an analytical reference standard for the determination of the analyte in plant and animal samples by high-performance liquid chromatography technique.

Uses

Shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Has a specific in vitro and in vivo antineuroectodermal tumor activity. Cathartic.

Definition

ChEBI: A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.

General Description

Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.

Biochem/physiol Actions

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Aloe emodin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Aloe emodin manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Aloe emodin 481-72-1
Price
US $225.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-03
Hebei Weibang Biotechnology Co., Ltd
Product
Aloe emodin 481-72-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Aloe emodin 481-72-1
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥99%
Supply Ability
20tons
Release date
2024-05-21

481-72-1, Aloe emodinRelated Search:

1,8-Dihydroxyanthraquinone Emodin-3-methyl ether methylol cellulose 2-Methyl anthraquinone Aloe vera aloe extract 1-Hydroxy anthraquinone DITHIANON Tris(hydroxymethyl)aminomethane Trimethylolpropane (10S)-BETA-D-GLUCOPYRANOSIDE-ALOE EMODIN,10-(1’,5’-anhydroglucosyl)aloe-emodin-9-anthron ALOESIN Aloin B Aloeresin D Torachrysone 8-O-glucoside Aloe-eModin-8-O-β-D-glucopyranoside Aloe-Emodin synthetic,ALOE EMODIN(P),ALOE EMODIN(SH),9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-, Aloe Emodin, Frangula Emodin, Rheum Emodin NOGALAMYCIN

  • 3-HydroxyMethylchrysazine
  • 1H-Indazole-3-carboxylic acid,4,5,6,7-tetrahydro-, ethyl ester
  • Aloe-eModol
  • NSC 38628
  • Diacerein IMpurity B
  • Aloe-eModine, froM RheuM palMatuM
  • 1,8-dihydroxy-3-(hydroxymethyl)-10-anthracenedione
  • 1,8-dihydroxy-3-hydroxymethyl-anthraquinon
  • 3-hydroxymethylchrysazin
  • rhabarberone
  • 1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9,10-ANTHRACENEDIONE
  • 1,8-DIHYDROXY-3-(HYDROXYMETHYL)ANTHRAQUINONE
  • ALOE-EMODIN
  • ALOE-EMODINE
  • 9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-(HYDROXYMETHYL)-
  • Aloeemodin:9,10-Anthracenedione,1,8-Dihydroxy-3-(Hydroxymethyl)-
  • 1,8-Dihydroxy-3-hydroxymethyl anthroquinone
  • RHA
  • RHUBARBERONE
  • ALOE EMODIN hplc
  • ALOE-EMODIN WITH HPLC
  • ALLYLPYRUVATE
  • 3-(hydroxymethyl)-
  • ALOE EMODIN(RG)
  • Aloe-emodin,1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone
  • Aloe-emodine, 98%, from Rheum palmatum L.
  • Aloe-emodin 481-72-1
  • Diacerein Impurity 3(Diacerein EP Impurity B)
  • Diacerein Impurity (Aloe-Emodin)
  • Aloe-emodine, 98%, from Rheum palmatum
  • Diacerein EP Impurity B
  • Diacerein EP Impurity B (Aloe Emodin)
  • Aloe emodin 50%-98%
  • 1,8-Dihydroxy-3-(hydroxymethyl)-ant
  • Diacerein impurity B CRS
  • Aloe Emodin &gt
  • C:C&B63
  • Aloe emodin USP/EP/BP
  • Aloe-emodin (Rhabarberone)
  • Aloe emodin (Diacerein Impurity)
  • Aloe-emodin, puriss 95%+
  • Diacerein impurity B (Y0001596)
  • 1,8-Dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
  • Diacetyl EP impurity B
  • 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione (aloe-emodin),
  • Aloe Emodin(AS)
  • Aloe emodin-RM
  • 481-72-1
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