ChemicalBook > CAS DataBase List > 2,3-Dimethoxyphenylboronic acid

2,3-Dimethoxyphenylboronic acid

Product Name
2,3-Dimethoxyphenylboronic acid
CAS No.
40972-86-9
Chemical Name
2,3-Dimethoxyphenylboronic acid
Synonyms
AKOS BRN-0202;3-Boronoveratrole;2,3-DimethoxyphenyL;2,3-DimethoxybenzeneboronicAci;2,3-dimethoxyphenylboronci acid;2,3-DIMETHOXYPHENYLBORONIC ACID;2,3-DIMETHOXYBENZENEBORONIC ACID;2,3-DiMethoxyphenylboronic acid 97%;B-(2,3-Dimethoxy-phenyl)boronic acid;2,3-Dimethoxyphenylboronic acid ,98%
CBNumber
CB6728027
Molecular Formula
C8H11BO4
Formula Weight
181.98
MOL File
40972-86-9.mol
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2,3-Dimethoxyphenylboronic acid Property

Melting point:
67-71 °C (lit.)
Boiling point:
347.9±52.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
8.12±0.58(Predicted)
form 
powder to crystal
color 
White to Almost white
BRN 
3051295
InChI
InChI=1S/C8H11BO4/c1-12-7-5-3-4-6(9(10)11)8(7)13-2/h3-5,10-11H,1-2H3
InChIKey
VREWSCMOGIXMDQ-UHFFFAOYSA-N
SMILES
B(C1=CC=CC(OC)=C1OC)(O)O
CAS DataBase Reference
40972-86-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-36/37-37
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557730
Product name
2,3-Dimethoxyphenylboronic acid
Purity
97%
Packaging
5g
Price
$83.7
Updated
2025/07/31
TCI Chemical
Product number
D3853
Product name
2,3-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
D3853
Product name
2,3-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$69
Updated
2025/07/31
Usbiological
Product number
273035
Product name
2,3-Dimethoxyphenylboronic acid
Packaging
1g
Price
$322
Updated
2021/12/16
TRC
Product number
D479203
Product name
2,3-Dimethoxyphenylboronic acid
Packaging
100mg
Price
$45
Updated
2021/12/16
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2,3-Dimethoxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

suzuki reaction

General Description

2,3-Dimethoxyphenylboronic acid is a useful research chemical for organic synthesis and other chemical processes.

Synthesis

91-16-7

121-43-7

40972-86-9

To a solution of N,N,N',N'-tetramethylethylenediamine (6.1 mL, 40.5 mmol) in diethyl ether (100 mL) was added n-butyllithium (26 mL, 1.6 M in hexane, 41.6 mmol) dropwise at 0° C. After 30 min the reaction mixture was cooled to -78° C., 1,2-dimethoxybenzene (5.0 g, 36.4 mmol) and stirred for 3 h at this temperature. Subsequently, trimethyl borate (9.7 mL, 86.4 mmol) was added, the cold bath was removed and the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was cooled to 0 °C, 150 mL of aqueous 2 M hydrochloric acid was added and stirred for 3 hours. The mixture was extracted with ethyl acetate (3 x 20 mL), the organic layers were combined, dried over magnesium sulfate, filtered, and concentrated in vacuum to afford 2,3-dimethoxyphenylboronic acid (1 g, 37% yield) as white crystals. 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (256 mg, 1.02 mmol) and 2,3-dimethoxyphenylboronic acid (370 mg, 2.03 mmol) were dissolved in DMSO (2 mL), and 2 M aqueous K3PO4 (1 mL) was added, followed by PdCl2 (dppf) (50 mg). The mixture was transferred to a microwave reaction tube and microwave irradiated at 120 °C for 15 min. After completion of the reaction, it was cooled to room temperature and the crude product was purified by column chromatography to afford 6-(2,3-dimethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline (190 mg, 61% yield) as a white solid. The product was brominated with N-bromosuccinimide, followed by a coupling reaction with 2-phenylethanethiol as described in Example 7 to give 45 mg of 2,3-dimethoxyphenylboronic acid as an oil.

References

[1] Chemical Communications, 1999, # 22, p. 2259 - 2260
[2] Patent: WO2004/18429, 2004, A2. Location in patent: Page 85
[3] Bulletin de la Societe Chimique de France, 1973, p. 767 - 769

2,3-Dimethoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

N,N,N',N'-Tetramethylethylenediamine 1,2-Dimethoxybenzene Diethyl ether Triisopropyl borate n-Butyllithium

Preparation Products

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View Lastest Price from 2,3-Dimethoxyphenylboronic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
(2,3-Dimethoxyphenyl)boronic acid 40972-86-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-23
Henan Fengda Chemical Co., Ltd
Product
(2,3-Dimethoxyphenyl)boronic acid 40972-86-9
Price
US $30.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,3-Dimethoxyphenylboronic acid 40972-86-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

40972-86-9, 2,3-Dimethoxyphenylboronic acidRelated Search:

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  • 2,3-DIMETHOXYBENZENEBORONIC ACID
  • 2,3-DIMETHOXYPHENYLBORONIC ACID
  • AKOS BRN-0202
  • 2,3-dimethoxyphenylboronci acid
  • 2,3-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
  • 2,3-Dimethoxyphenylboronic acid ,98%
  • 3-Boronoveratrole
  • 2,3-DiMethoxyphenylboronic acid 97%
  • B-(2,3-Dimethoxy-phenyl)boronic acid
  • 2,3-Dimethoxybenzeneboronic Acid (contains varying amounts of Anhydride)
  • 2,3-DimethoxyphenylboronicAcid(containsvaryingamountsofAnhydride)&gt
  • 2,3-DimethoxyphenyL
  • Boronic acid, B-(2,3-dimethoxyphenyl)-
  • 2,3-DimethoxybenzeneboronicAci
  • 2,3-Dimethoxybenzeneboronic acid - [D2715]
  • 40972-86-9
  • 40912-86-9
  • 40792-86-9
  • C6H3OCH32BOH2
  • Organometallic Reagents
  • Aryl
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Organoborons
  • Boronic acids
  • Boronic Acid
  • Aryl