ChemicalBook > CAS DataBase List > 3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
177947-96-5
Chemical Name
3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
TERT-BUTYL 3-FORMYLAZETIDINE-1-CARBOXYLATE;1-Boc-3-azetidinecarboxaldehyde;1-Boc-3-forMylazetidine;N-BOC-3-formylazetidine;3-Formyl 1-BOC-N-Azetidine;1-Boc-azetidine-3-carboxa...;1-Boc-azetidine-3-carboxaldehyde;1-Boc-azetidine-3-carboxaldehyde,97%;1-Boc-azetidine-3-carboxaldehyde, 97%;ert-butyl3-formylazetidine-1-carboxylate
CBNumber
CB6733292
Molecular Formula
C9H15NO3
Formula Weight
185.22
MOL File
177947-96-5.mol
More
Less

3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:
257℃
Density 
1.188
refractive index 
1.4600 to 1.4640
Flash point:
109℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
clear liquid
pka
-2.70±0.40(Predicted)
color 
Colorless to Light yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h6-7H,4-5H2,1-3H3
InChIKey
JVQOZRRUGOADSU-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(C=O)C1
More
Less

Safety

Hazard Codes 
Xi
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B5160
Product name
1-(tert-Butoxycarbonyl)azetidine-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
200mg
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
B5160
Product name
1-(tert-Butoxycarbonyl)azetidine-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$157
Updated
2025/07/31
TRC
Product number
B810095
Product name
tert-Butyl3-Formylazetidine-1-carboxylate
Packaging
500mg
Price
$155
Updated
2021/12/16
Synthonix
Product number
A0179
Product name
tert-butyl3-Formylazetidine-1-carboxylate
Purity
95%
Packaging
100mg
Price
$25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141779
Product name
1-Boc-3-azetidinecarboxaldehyde
Packaging
250mg
Price
$55
Updated
2021/12/16
More
Less

3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

3-Formylazetidine-1-carboxylic acid tert-butyl ester is a white to pale yellow solid compound with high reactivity and selectivity, which can be used to prepare a variety of compounds with specific functions.

Uses

1-Boc-azetidine-3-carboxaldehyde is used as a starting material in organic synthesis. It is also used as an intermediate in pharmaceuticals.

Synthesis

142253-56-3

177947-96-5

The general procedure for the synthesis of tert-butyl 3-formylazetidine-1-carboxylate from 1-Boc-3-hydroxymethylazetidine was as follows: to a stirred solution of oxalyl chloride (4.28 mL, 49.8 mmol) in dichloromethane (DCM, 5 mL) was added slowly and dropwise to dimethylsulfoxide (DMSO, 0.71 mL, 9.96 mmol) at -78 °C. The reaction mixture was continued to be stirred at this temperature for 15 minutes. Subsequently, tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (0.69 g, 3.69 mmol) was added and triethylamine (2.1 mL, 14.75 mmol) was added immediately. The reaction system was gradually warmed to room temperature and diluted with DCM (30 mL). The reaction solution was washed with water and the organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (using an Isolute column, eluent: heptane/ethyl acetate gradient, 0-100%) to give tert-butyl 3-formylazetidine-1-carboxylate (0.19 g, 27% yield).

References

[1] Patent: WO2014/165075, 2014, A1. Location in patent: Page/Page column 45; 46
[2] Patent: US2014/171402, 2014, A1. Location in patent: Paragraph 0053; 0054; 0055; 0056
[3] Patent: EP2754653, 2014, A2. Location in patent: Paragraph 0044; 0045
[4] Patent: WO2018/89355, 2018, A1. Location in patent: Page/Page column 102-104
[5] Patent: WO2010/80357, 2010, A1. Location in patent: Page/Page column 45-46

3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Acetonitrile Potassium bicarbonate Palladium hydroxide Sodium sulfate Toluene Di-tert-butyl dicarbonate Benzylamine Formaldehyde Potassium carbonate N,N-Diisopropylethylamine Sodium borohydride Triethylamine Isopropyl chloroformate Methanesulfonyl chloride 1,4-Dioxane Tetrahydrofuran Trifluoroacetic anhydride Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Methanol Dimethyl sulfoxide Oxalyl chloride Sodium hydroxide Diethyl malonate

Preparation Products

More
Less

3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Americas 1 Canada 1 China 148 Europe 1 India 3 Japan 1 United Kingdom 2 United States 15 Global 172
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
37023730
Email
info@carlowchem.com
Country
China
ProdList
1922
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
SY06@accelachem.com
Country
China
ProdList
7551
Advantage
58
Shanghai Kailedia Biopharmaceutical Co., Ltd
Tel
021-18800336901 18800336901
Email
muyouren139@163.com
Country
China
ProdList
179
Advantage
58
Heifei Yuanzhi Pharmaceutical R&D Co.,Ltd
Tel
0551-68136310 18705595789
Fax
0551-68136307
Email
939249921@qq.com
Country
China
ProdList
46
Advantage
55
BTC Pharmaceutical CO. Ltd
Tel
15716293042 18862996710
Fax
0513-68015394
Email
15050603958@163.com
Country
China
ProdList
695
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
1009
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Atop-Pharma (Shanghai) Technology Co., Ltd.
Tel
+86 (21) 5196-9732
Fax
+86 (21) 5196-9733
Country
China
ProdList
996
Advantage
57
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai potentpharm CO.,Ltd
Tel
(86) 21 51969655
Fax
(86) 21 51969655， QQ：33109286， 263541193
Country
China
ProdList
487
Advantage
22
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Sheepchem Co., Ltd.
Tel
+86 (21) 6715-7650
Fax
+86 (21) 6715-7651
Email
sheepchem@163.com
Country
China
ProdList
994
Advantage
60
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
023-13650506873 19923294409
Email
xingcanyaoye@sina.com
Country
China
ProdList
1604
Advantage
58
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Shanghai Mixiu Chemical Co., Ltd.
Tel
18101936766
Fax
021-58583907
Email
eileen@shmychem.com
Country
China
ProdList
350
Advantage
55
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Chongqing Kangheyuecheng Pharmaceutical Technology Co., Ltd.
Tel
023-61183015; 13271886913
Email
kangheyuecheng@163.com
Country
China
ProdList
292
Advantage
55
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
LinkChem Technology Co., Ltd.
Tel
021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
3000
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8595
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Beijing Shuoqi Science And Technology Co., Ltd.
Tel
18610542700
Fax
010-69737341
Email
3138545@qq.com
Country
China
ProdList
298
Advantage
58
More
Less

View Lastest Price from 3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Henan Fengda Chemical Co., Ltd
Product
3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 177947-96-5
Price
US $10.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-12
Career Henan Chemical Co
Product
3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 177947-96-5
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-23

177947-96-5, 3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

Methyl 3-formylbenzoate 2-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(2-CYANO-ACETYL)-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-3-Azetidinecarboxylic acid AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER Methyl 1-Boc-azetidine-3-carboxylate

  • 1-(tert-Butoxycarbonyl)-3-azetidinecarboxaldehyde
  • 1-Boc-azetidine-3-carboxaldehyde, 97%
  • 1-Boc-3-forMylazetidine
  • tert-Butyl 3-formylazetidine-1-carboxylate, N-(tert-Butoxycarbonyl)azetane-3-carboxaldehyde
  • 1-(tert-Butoxycarbonyl)azetidine-3-carboxaldehyde
  • 1-(<i>tert</i>-Butoxycarbonyl)azetidine-3-carboxaldehyde
  • TERT-BUTYL 3-FORMYLAZETIDINE-1-CARBOXYLATE
  • 3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-Boc-3-azetidinecarboxaldehyde
  • Azetidine-3-carboxaldehyde, N1-BOC protected
  • 1-Boc-azetidine-3-carboxa...
  • Azetidine-3-carboxaldehyde, N-BOC protected
  • Tert butyl 3-formyl azacyclobutane-1-carboxylic acid
  • N-BOC-3-formylazetidine
  • 1-Azetidinecarboxylic acid, 3-formyl-, 1,1-dimethylethyl ester
  • 1-Boc-azetidine-3-carboxaldehyde,97%
  • ert-butyl3-formylazetidine-1-carboxylate
  • 3-Formyl 1-BOC-N-Azetidine
  • tert-butyl 3-Formylazetidine-1-carboxylate - [A0179]
  • 1-Boc-azetidine-3-carboxaldehyde
  • 177947-96-5
  • Factory