CYTOCHALASIN A

ChemicalBook > CAS DataBase List > CYTOCHALASIN A

Product Name: CYTOCHALASIN A
CAS No.: 14110-64-6
Chemical Name: CYTOCHALASIN A
Synonyms: Dehydrophomin;CYTOCHALASIN A;CYTOCHALASIN A(RG);5,5-Didehydrophomin;Cytochalasin dreschslera dematioidea;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA;CytochalasinA from Drechslera dematioidea;cytochalasin a from helminthosporium dematioideum;Cytochalasin A 5-Dehydrophomin Dehydrophomin;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 99.0% (TLC)
CBNumber: CB6735221
Molecular Formula: C29H35NO5
Formula Weight: 477.59
MOL File: 14110-64-6.mol

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CYTOCHALASIN A Property

Melting point:: 190-191 °C
Boiling point:: 725.1±60.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: ethanol: 20 mg/mL, clear, colorless
form: Powder
pka: 13.54±0.70(Predicted)
color: White
Water Solubility: Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
Sensitive: Light Sensitive
BRN: 949521
LogP: 1.849 (est)
EPA Substance Registry System: Cytochalasin A (14110-64-6)

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Safety

Hazard Codes: T+,T
Risk Statements: 26/27/28-63
Safety Statements: 28-36/37-45
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
F: 10
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6637
Product name: Cytochalasin A from Drechslera dematioidea
Packaging: 1mg
Price: $163
Updated: 2024/03/01

Alfa Aesar

Product number: J60280
Product name: Cytochalasin A
Packaging: 1mg
Price: $91.6
Updated: 2021/12/16

Alfa Aesar

Product number: J60280
Product name: Cytochalasin A
Packaging: 5mg
Price: $352
Updated: 2021/12/16

Cayman Chemical

Product number: 11327
Product name: Cytochalasin A
Purity: ≥98%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 11327
Product name: Cytochalasin A
Purity: ≥98%
Packaging: 5mg
Price: $195
Updated: 2024/03/01

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CYTOCHALASIN A Chemical Properties,Usage,Production

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC₅₀ = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (K_i = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

Chemical Properties

white powder

Uses

Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins exhibiting activity against HIV-1 protease.

Uses

Cytochalasin A binds to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Preventing growth and sugar uptake in a Saccharomyces strain.

Definition

ChEBI: Cytochalasin A is a cytochalasin.

Biochem/physiol Actions

Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

CYTOCHALASIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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14110-64-6, CYTOCHALASIN ARelated Search:

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14110-64-6

C29H35NO5

Other

Cytoskeleton and Extracellular Matrix

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Cytoskeleton and Extracellular Matrix

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