ChemicalBook > CAS DataBase List > 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

Product Name: 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
CAS No.: 42895-58-9
Chemical Name: 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Synonyms: AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;Deoxy 11,14-didehydroandrographolide;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-
CBNumber: CB6735337
Molecular Formula: C20H28O4
Formula Weight: 332.43
MOL File: 42895-58-9.mol

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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Property

Melting point:: 204-205℃
Boiling point:: 519.6±50.0 °C(Predicted)
Density: 1.17
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
pka: 14.80±0.70(Predicted)
form: Solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89631
Product name: 14-Deoxy-11,12-didehydroandrographolide
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $614
Updated: 2025/07/31

Sigma-Aldrich

Product number: 55549
Product name: 14-Deoxy-11,12-didehydroandrographolide
Purity: analytical standard
Packaging: 5mg
Price: $439
Updated: 2025/07/31

Cayman Chemical

Product number: 11670
Product name: 14-deoxy-11,12-didehydro Andrographolide
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 11670
Product name: 14-deoxy-11,12-didehydro Andrographolide
Purity: ≥98%
Packaging: 1mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 11670
Product name: 14-deoxy-11,12-didehydro Andrographolide
Purity: ≥98%
Packaging: 5mg
Price: $263
Updated: 2024/03/01

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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Usage,Production

Description

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED₅₀ >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

Uses

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

Definition

ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.

in vivo

14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine^[1].

IC 50

NF-κB

References

[1] WENKUI LI. Secondary metabolites from Andrographis paniculata.[J]. Chemical & pharmaceutical bulletin, 2007, 55 3: 455-458. DOI: 10.1248/cpb.55.455
[2] K. JARUKAMJORN N N. Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide[J]. Journal of Health Science, 2008, 38 1: 370-381. DOI: 10.1248/jhs.54.370

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Suppliers

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View Lastest Price from 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE manufacturers

Dideu Industries Group Limited

Product: 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-21

Shaanxi Dideu Medichem Co. Ltd

Product: 14-Deoxy-11,12-didehydroandrographolide 42895-58-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 tons
Release date: 2020-05-01

Career Henan Chemical Co

Product: 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
Price: US $8.00/KG
Min. Order: 1KG
Purity: ＞98% HPLC
Supply Ability: 20 tons
Release date: 2020-02-17

42895-58-9, 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDERelated Search:

β-Elemonic Acid Carboxyatractyloside DARUTOSIDE dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate 10-Deacetylbaccatin III DARUTIGENOL 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one 11-Hydroxy-sugiol ANDROGRAPHOLIDE, DEOXY- Dehydroandrographolide Andrographis Paniculata PE 14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE DEHYDROANDROGRAPHOLIDESUCCINATE Andrographolide AKOS NCG1-0062 3-[2-(6-HYDROXY-5-HYDROXYMETHYL-5,8A-DIMETHYL-2-METHYLENE-DECAHYDRO-NAPHTHALEN-1-YL)-VINYL]-5H-FURAN-2-ONE 4-[1-(3-CARBOXYLATOPROPANOYLOXYMETHYL)-1,4A-DIMETHYL-6-METHYLIDENE-5-[2-(2-OXO-5H-FURAN-3-YL)ETHENYL]DECALIN-2-YL]OXY-4-OXO-BUTANOATE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone

ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide

11,12-Didehydro-14-deoxyandrographolide

14-Deoxy-11,14-didehydroandrographolide

AP 10

Deoxy-11,12-Didehydroandrographolide, 14-

3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one

3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one

3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one

14-Deoxy-11,12-didehydroandrographol

14-Deoxy-11,12-didehydroandrographolide16,15-olide

3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide

3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one

14-Deoxy-11,12-didehydroandrographolide?, >98%

2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-

14-dehydro Andrographolide

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP

Andrographolide Impurity 1

4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one

14-deoxy11,12 deoxyandrographolide

14 - deoxy11,12-12 dehydroandrographolide

14-Deoxy 11,14-didehydroandrographolide-RM

Deoxy 11,14-didehydroandrographolide

14-Deoxy-11,12-didehydroandrographolide, 10 mM in DMSO

42895-58-9