ChemicalBook > CAS DataBase List > 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
- Product Name
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
- CAS No.
- 42895-58-9
- Chemical Name
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
- Synonyms
- AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;Deoxy 11,14-didehydroandrographolide;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-
- CBNumber
- CB6735337
- Molecular Formula
- C20H28O4
- Formula Weight
- 332.43
- MOL File
- 42895-58-9.mol
More
Less
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Property
- Melting point:
- 204-205℃
- Boiling point:
- 519.6±50.0 °C(Predicted)
- Density
- 1.17
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
- pka
- 14.80±0.70(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
Safety
- WGK Germany
- 3
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHL89631
- Product name
- 14-Deoxy-11,12-didehydroandrographolide
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $574
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 55549
- Product name
- 14-Deoxy-11,12-didehydroandrographolide
- Purity
- analytical standard
- Packaging
- 5mg
- Price
- $426
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11670
- Product name
- 14-deoxy-11,12-didehydro Andrographolide
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11670
- Product name
- 14-deoxy-11,12-didehydro Andrographolide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $87
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11670
- Product name
- 14-deoxy-11,12-didehydro Andrographolide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $263
- Updated
- 2024/03/01
More
Less
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Usage,Production
Description
14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.
Uses
14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
Definition
ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Suppliers
- Tel
- --
- Fax
- --
- Country
- Germany
- ProdList
- 1136
- Advantage
- 62
More
Less
View Lastest Price from 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE manufacturers
Dideu Industries Group Limited
- Product
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-21
Shaanxi Dideu Medichem Co. Ltd
- Product
- 14-Deoxy-11,12-didehydroandrographolide 42895-58-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 tons
- Release date
- 2020-05-01
Career Henan Chemical Co
- Product
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 42895-58-9
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- ＞98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-17
42895-58-9, 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDERelated Search:
β-Elemonic Acid
Carboxyatractyloside
DARUTOSIDE
dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
10-Deacetylbaccatin III
DARUTIGENOL
3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one
11-Hydroxy-sugiol
ANDROGRAPHOLIDE, DEOXY-
Dehydroandrographolide
Andrographis Paniculata PE
14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
DEHYDROANDROGRAPHOLIDESUCCINATE
Andrographolide
AKOS NCG1-0062
3-[2-(6-HYDROXY-5-HYDROXYMETHYL-5,8A-DIMETHYL-2-METHYLENE-DECAHYDRO-NAPHTHALEN-1-YL)-VINYL]-5H-FURAN-2-ONE
4-[1-(3-CARBOXYLATOPROPANOYLOXYMETHYL)-1,4A-DIMETHYL-6-METHYLIDENE-5-[2-(2-OXO-5H-FURAN-3-YL)ETHENYL]DECALIN-2-YL]OXY-4-OXO-BUTANOATE