2-Thiopheneethanol

Product Name: 2-Thiopheneethanol
CAS No.: 5402-55-1
Chemical Name: 2-Thiopheneethanol
Synonyms: THIOPHENE-2-ETHANOL;2-(thiophen-2-yl)ethan-1-ol;Thiopheneethanol;2-THIOPHENETHANOL;2-THIENYLETHANOL;2-THIOPHENEETHANOL;2- thiophenealcohol;2-Thiophenylethanol;THIOPHENE-2-ETHYANOL;B-(B-THIENYL)ETHANOL
CBNumber: CB6735579
Molecular Formula: C6H8OS
Formula Weight: 128.19
MOL File: 5402-55-1.mol

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2-Thiopheneethanol Property

Boiling point:: 108-109 °C/13 mmHg (lit.)
Density: 1.153 g/mL at 25 °C (lit.)
refractive index: n20/D 1.551(lit.)
Flash point:: 214 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Liquid
pka: 14.77±0.10(Predicted)
color: Clear light yellow to gray-green or brownish
Water Solubility: slightly soluble
BRN: 106985
LogP: 1.040 (est)
CAS DataBase Reference: 5402-55-1(CAS DataBase Reference)
NIST Chemistry Reference: 2-Thiopheneethanol(5402-55-1)
EPA Substance Registry System: 2-Thiopheneethanol (5402-55-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26
RIDADR: UN 3334
WGK Germany: 3
F: 13
Hazard Note: Irritant
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T27855
Product name: 2-Thiopheneethanol
Purity: 98%
Packaging: 5g
Price: $42.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: T27855
Product name: 2-Thiopheneethanol
Purity: 98%
Packaging: 25g
Price: $121.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18682
Product name: Thiophene-2-ethanol
Purity: for synthesis
Packaging: 25mL
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: T1021
Product name: 2-Thiopheneethanol
Purity: >98.0%(GC)
Packaging: 25mL
Price: $44
Updated: 2025/07/31

Sigma-Aldrich

Product number: T27855
Product name: 2-Thiopheneethanol
Purity: 98%
Packaging: 100g
Price: $607
Updated: 2023/06/20

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2-Thiopheneethanol Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly brown liquid

Uses

2-Thiopheneethanol is a thiophene derivative used in the preparation of oligothiophene isothiocyanates as fluorescent markers for biopolymers. 2-Thiopheneethanol is also used in the preparation of oth er biologically active compounds such as the analgesic Sulfentanyl and the antithrombotic Clopidogrel Hydrogen Sulfate (C587250).

Uses

2-Thiopheneethanol, is used as the antithrombotics thiophene chlorine match piperidine intermediates. It is also used as a ticlopidine Intermediate.

Definition

ChEBI: 2-(2-Thienyl)ethanol is a heteroarene.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 477, 1942 DOI: 10.1021/ja01255a001
The Journal of Organic Chemistry, 59, p. 4323, 1994 DOI: 10.1021/jo00094a056

Synthesis

1918-77-0

5402-55-1

2.3. Biotransformation experiments: liquid culture inoculum was prepared by pre-culturing the fungal strains in Petri dishes containing malt extract solid medium (MEA: glucose 20 g/L, malt extract 20 g/L, agar 20 g/L, peptone 2 g/L). The fungus was inoculated as a conidial suspension (1 × 10^6 conidia/mL) in a 50 mL conical flask containing 40 mL of malt extract liquid medium. The conical flasks were placed in a constant temperature shaker at 25°C and incubated with oscillation at 110 rpm. After 2 days of preincubation, a DMSO solution with 500 mM substrate was added to give a starting substrate concentration (c0) of 1-5 mM. Three biological replicates were set up for each substrate. After addition of substrate, the experiment continued for 3 days, during which time 1 mL was sampled at predetermined time intervals (typically 24, 48, and 72 h.) After each sampling, the sample was extracted with 500 μL of ethyl acetate (EtOAc), and the organic phase was dried over anhydrous Na2SO4 and analyzed by GC/MS. In some cases (see Section 2.4), the reduction products were separated. Before each set of biotransformation experiments, initial biomass and pH were determined. At the end of the experiment, these parameters were evaluated again. The liquid medium was separated from the biomass by filtration for pH measurements; mycelium was dried at 60°C for 24 h and the dry weight of the biomass was determined. The yield of the product 2-(thiophen-2-yl)ethanol was 72% (3.7 mg) and the yield of the by-product methyl 2-(thiophen-2-yl)acetate was 96% (24.6 mg).1H NMR (400 MHz, CDCl3, TMS): δ = 7.20 (m, 1H, heteroaromatic hydrogens), 6.99 (m, 1H, heteroarylhydrogen), 6.90 (m, 1H, heteroaromatic hydrogen), 3.85 (t, 2H, J=6.2 Hz, CH2OH), 3.02 (t, 2H, J=6.2 Hz, CH2CH2OH). 13C NMR (100 MHz, CDCl3, TMS): δ=140.5, 127.0, 125.8, 124.0, 63.4, 33.3. GC/MS: tR= 9.47 min, m/z 128 (M+, 30%), 110 (5%), 97 (100%).

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 3, p. 346 - 357
[2] Chemical Communications (Cambridge, United Kingdom), 2012, vol. 48, # 85, p. 10514 - 10516,3
[3] European Journal of Organic Chemistry, 2011, # 17, p. 3178 - 3183
[4] Journal of Molecular Catalysis B: Enzymatic, 2015, vol. 116, p. 83 - 88
[5] Patent: US2010/16365, 2010, A1. Location in patent: Page/Page column 26

2-Thiopheneethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Thiopheneethanol manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Thiopheneethanol 5402-55-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Thiopheneethanol 5402-55-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kgs
Release date: 2021-07-30

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Thiopheneethanol 5402-55-1
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2025-03-10

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5402-55-1

5017-42-1

ALCOHOL

Building Blocks

Thiophenes

Heterocyclic Building Blocks

Alkohols

Heterocyclic Compounds

Thiophens

Thiophene&Benzothiophene

Heterocycles