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3-PHENYLAMINO-PROPIONIC ACID

Product Name
3-PHENYLAMINO-PROPIONIC ACID
CAS No.
5652-38-0
Chemical Name
3-PHENYLAMINO-PROPIONIC ACID
Synonyms
NSC 54626;3-(Phenylamino);N-Phenyl-b-alanine;RARECHEM AL BO 0162;β-Alanine, N-phenyl-;N-PHENYL-BETA-ALANINE;3-Anilinopropionic acid;3-Anilinopropanoic acid;3-Phenylammoniopropanoate;N-(2-Carboxyethyl)aniline
CBNumber
CB6740092
Molecular Formula
C9H11NO2
Formula Weight
165.19
MOL File
5652-38-0.mol
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3-PHENYLAMINO-PROPIONIC ACID Property

Melting point:
218-221℃
Boiling point:
364.6±25.0 °C(Predicted)
Density 
1.209±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C(protect from light)
pka
3.58±0.12(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P319638
Product name
3-(Phenylamino)propanoicAcid
Packaging
100mg
Price
$40
Updated
2021/12/16
TRC
Product number
P319638
Product name
3-(Phenylamino)propanoicAcid
Packaging
1g
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-W021779
Product name
3-(Phenylamino)propanoicacid
Purity
97.16%
Packaging
1g
Price
$22
Updated
2021/12/16
Matrix Scientific
Product number
126965
Product name
3-(Phenylamino)propanoicacid
Purity
>95%
Packaging
1g
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-W021779
Product name
3-(Phenylamino)propanoicacid
Purity
97.16%
Packaging
5g
Price
$109
Updated
2021/12/16
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3-PHENYLAMINO-PROPIONIC ACID Chemical Properties,Usage,Production

Uses

3-(Phenylamino)propanoic Acid is used in the preparation of spiroheterocycles as filamin A (FLNA) binding antiinflammatory analgesics.

Synthesis

57-57-8

62-53-3

5652-38-0

The general procedure for the synthesis of 3-anilinopropionic acid from β-propiolactone and aniline was as follows: aniline (5.00 g) was dissolved in acetonitrile (30 ml) and heated to reflux. Subsequently, β-propiolactone (3.36 ml) was added slowly and dropwise. The reflux condition was maintained and the reaction was continued for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in aqueous sodium hydroxide solution and the aqueous phase was washed with ether. The pH of the aqueous phase was adjusted to 4-5 with hydrochloric acid and subsequently extracted with ether. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=9:1) to afford the target product 3-anilinopropionic acid (2.08 g, 23% yield).

References

[1] Patent: EP1452526, 2004, A1. Location in patent: Page 105
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3168,3171
[3] Patent: US2008/153871, 2008, A1. Location in patent: Page/Page column 24

3-PHENYLAMINO-PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-PHENYLAMINO-PROPIONIC ACID manufacturers

Career Henan Chemical Co
Product
3-PHENYLAMINO-PROPIONIC ACID 5652-38-0
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

5652-38-0, 3-PHENYLAMINO-PROPIONIC ACIDRelated Search:

ETHYL 3-HYDROXY-4,6-DIMETHOXY-2-OXOINDOLINE-3-CARBOXYLATE 3-Amino-3-phenylpropionic acid 3-(2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL)PROPANOIC ACID CLORAZEPATE DIPOTASSIUM SALT DNP-L-ASPARTIC ACID Vincristine sulfate 3-PHENYLAMINO-PROPIONIC ACID AURORA 3455 DNP-BETA-ALANINE ANTIPYRINECARBOXYLIC ACID 3-PHENYLAMINO-PROPIONIC ACID METHYL ESTER 1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER ETHYL 3-(4-METHOXYANILINO)PROPANOATE AURORA 9261 2-[(5-(2-(3-CARBOXYETHYL-5,6-DIMETHYL-2-BENZOXAZOLINYLIDENE) ETHYLIDENE]-4-OXO-3-PHENYL-2-THIAZOLIDINYLIDENE]METHYL)5-CHLORO-3-ETHYL BENZOTHIAZOLIUM BROMIDE methyl 3-[(2-cyanoethyl)(phenyl)amino]propanoate 1,2,3,4-TETRAHYDROQUINOLINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER AURORA 2031

  • RARECHEM AL BO 0162
  • N-PHENYL-BETA-ALANINE
  • 3-(PHENYLAMINO)PROPANOIC ACID
  • 3-PHENYLAMINO-PROPIONIC ACID
  • 3-Anilinopropanoic acid
  • 3-Anilinopropionic acid
  • N-(2-Carboxyethyl)aniline
  • NSC 54626
  • N-Phenyl-b-alanine
  • 3-(Phenylamino)
  • 3-Phenylammoniopropanoate
  • β-Alanine, N-phenyl-
  • 5652-38-0
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Beta-Amino Acids