3-PHENYLAMINO-PROPIONIC ACID
- Product Name
- 3-PHENYLAMINO-PROPIONIC ACID
- CAS No.
- 5652-38-0
- Chemical Name
- 3-PHENYLAMINO-PROPIONIC ACID
- Synonyms
- NSC 54626;3-(Phenylamino);N-Phenyl-b-alanine;RARECHEM AL BO 0162;β-Alanine, N-phenyl-;N-PHENYL-BETA-ALANINE;3-Anilinopropionic acid;3-Anilinopropanoic acid;3-Phenylammoniopropanoate;N-(2-Carboxyethyl)aniline
- CBNumber
- CB6740092
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 5652-38-0.mol
3-PHENYLAMINO-PROPIONIC ACID Property
- Melting point:
- 218-221℃
- Boiling point:
- 364.6±25.0 °C(Predicted)
- Density
- 1.209±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.58±0.12(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P319638
- Product name
- 3-(Phenylamino)propanoicAcid
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- P319638
- Product name
- 3-(Phenylamino)propanoicAcid
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-W021779
- Product name
- 3-(Phenylamino)propanoicacid
- Purity
- 97.16%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 126965
- Product name
- 3-(Phenylamino)propanoicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-W021779
- Product name
- 3-(Phenylamino)propanoicacid
- Purity
- 97.16%
- Packaging
- 5g
- Price
- $109
- Updated
- 2021/12/16
3-PHENYLAMINO-PROPIONIC ACID Chemical Properties,Usage,Production
Uses
3-(Phenylamino)propanoic Acid is used in the preparation of spiroheterocycles as filamin A (FLNA) binding antiinflammatory analgesics.
Synthesis
57-57-8
62-53-3
5652-38-0
The general procedure for the synthesis of 3-anilinopropionic acid from β-propiolactone and aniline was as follows: aniline (5.00 g) was dissolved in acetonitrile (30 ml) and heated to reflux. Subsequently, β-propiolactone (3.36 ml) was added slowly and dropwise. The reflux condition was maintained and the reaction was continued for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in aqueous sodium hydroxide solution and the aqueous phase was washed with ether. The pH of the aqueous phase was adjusted to 4-5 with hydrochloric acid and subsequently extracted with ether. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=9:1) to afford the target product 3-anilinopropionic acid (2.08 g, 23% yield).
References
[1] Patent: EP1452526, 2004, A1. Location in patent: Page 105
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3168,3171
[3] Patent: US2008/153871, 2008, A1. Location in patent: Page/Page column 24
3-PHENYLAMINO-PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-PHENYLAMINO-PROPIONIC ACID Suppliers
- Tel
- --
- Fax
- --
- enamine@enamine.net
- Country
- Ukraine
- ProdList
- 6216
- Advantage
- 67
View Lastest Price from 3-PHENYLAMINO-PROPIONIC ACID manufacturers
- Product
- 3-PHENYLAMINO-PROPIONIC ACID 5652-38-0
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08