8-Bromomethylquinoline
Uses- Product Name
- 8-Bromomethylquinoline
- CAS No.
- 7496-46-0
- Chemical Name
- 8-Bromomethylquinoline
- Synonyms
- 8-(BROMOMETHYL)QUINOLINE;8-QuinolylMethyl broMide;8-Quinolinylmethyl bromide;Quinoline, 8-(bromomethyl)-;8-(Bromomethyl)quinoline ,97%;8-(Bromomethyl)-1-azanaphthalene;8-(Bromomethyl)quinoline >=96.5% (GC);8-Bromomethylquinoline ISO 9001：2015 REACH
- CBNumber
- CB6746342
- Molecular Formula
- C10H8BrN
- Formula Weight
- 222.08
- MOL File
- 7496-46-0.mol
8-Bromomethylquinoline Property
- Melting point:
- 81 °C
- Boiling point:
- 321.9±17.0 °C(Predicted)
- Density
- 1.518±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Dichloromethane
- form
- Solid
- pka
- 3.85±0.17(Predicted)
- color
- White
- BRN
- 119140
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 34-22-52-41
- Safety Statements
- 26-36/37/39-45-24/25-22-39
- RIDADR
- 3261
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- IRRITANT
- HS Code
- 29334900
N-Bromosuccinimide Price
- Product number
- 727512
- Product name
- 8-(Bromomethyl)quinoline
- Purity
- ≥96.5% (GC)
- Packaging
- 1g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- 727512
- Product name
- 8-(Bromomethyl)quinoline
- Purity
- ≥96.5% (GC)
- Packaging
- 5g
- Price
- $469
- Updated
- 2025/07/31
- Product number
- B679240
- Product name
- 8-Bromomethylquinoline
- Packaging
- 2.5g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- B679240
- Product name
- 8-Bromomethylquinoline
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK100125
- Product name
- 8-(Bromomethyl)quinoline
- Purity
- 97%
- Packaging
- 500mg
- Price
- $78
- Updated
- 2021/12/16
8-Bromomethylquinoline Chemical Properties,Usage,Production
Uses
8-Bromomethylquinoline is an intermediate in synthesizing 8-Quinolinemethanamine Dihydrochloride (Q700700), which is a salt form of 8-Quinolinemethanamine. 8-Quinolinemethanamine is used in the preparation of quinazolinone derivatives as anti-tumor agents.
Chemical Properties
Light yellow powder
Uses
8-Bromomethylquinoline is an intermediate in synthesizing 8-Quinolinemethanamine Dihydrochloride (Q700700), which is a salt form of 8-Quinolinemethanamine. 8-Quinolinemethanamine is used in the preparation of quinazolinone derivatives as anti-tumor agents.
Synthesis
611-32-5
7496-46-0
To a pre-dried 300 mL three-necked flask under nitrogen atmosphere were added 8-methylquinoline (10.0 g, 69.8 mmol), benzoyl peroxide (0.843 g, 3.49 mmol) and cyclohexane (150 mL). Under stirring conditions, N-bromosuccinimide (13.6 g, 76.8 mmol) was added in batches. The reaction mixture was refluxed for 10 hours. After completion of the reaction, the reaction mixture was filtered. The filtrate was washed sequentially with saturated aqueous sodium bicarbonate (3 x 100 mL) and brine (100 mL) and then dried with anhydrous sodium sulfate. Subsequently, the solvent was removed by vacuum evaporation. Finally, recrystallization was carried out using ether and hexane to give the light brown solid product 8-bromomethylquinoline (7.1 g, 46% yield).
References
[1] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 1, p. 1 - 9
[2] Journal of Organometallic Chemistry, 1994, vol. 484, # 1-2, p. C8 - C9
[3] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1995, # 13, p. 2289 - 2296
[4] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 4, p. 477 - 479
[5] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 8, p. 2109 - 2116
8-Bromomethylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Bromomethylquinoline manufacturers
- Product
- 8-(Bromomethyl)quinoline 7496-46-0
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 8-Bromomethylquinoline 7496-46-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23
- Product
- 8-Bromomethylquinoline 7496-46-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22