VESNARINONE
- Product Name
- VESNARINONE
- CAS No.
- 81840-15-5
- Chemical Name
- VESNARINONE
- Synonyms
- Arkin;CS-2139;0PC-8212;OPC 8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
- CBNumber
- CB6750484
- Molecular Formula
- C22H25N3O4
- Formula Weight
- 395.45
- MOL File
- 81840-15-5.mol
VESNARINONE Property
- Melting point:
- 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
- Boiling point:
- 519.41°C (rough estimate)
- Density
- 1.2414 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM) - form
- A crystalline solid
- pka
- 2.86(at 25℃)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23489
- Product name
- Vesnarinone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23489
- Product name
- Vesnarinone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 23489
- Product name
- Vesnarinone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 23489
- Product name
- Vesnarinone
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- CS-5387
- Product name
- Vesnarinone
- Purity
- 96.06%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
VESNARINONE Chemical Properties,Usage,Production
Description
Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.
Description
Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
Originator
Otsuka (Japan)
Uses
Cardiotonic.
Definition
ChEBI: Arkin (TN) is an organic molecular entity.
brand name
Arkin (Otsuka America);Arkin-Z.
VESNARINONE Preparation Products And Raw materials
Raw materials
Preparation Products
VESNARINONE Suppliers
View Lastest Price from VESNARINONE manufacturers
- Product
- Vesnarinone 81840-15-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-11
- Product
- VESNARINONE 81840-15-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-12