ChemicalBook > CAS DataBase List > 2-BROMO-4-PHENYLPYRIDINE
2-BROMO-4-PHENYLPYRIDINE
Uses- Product Name
- 2-BROMO-4-PHENYLPYRIDINE
- CAS No.
- 54151-74-5
- Chemical Name
- 2-BROMO-4-PHENYLPYRIDINE
- Synonyms
- Methyl 2-bromo-4-phenylpyridine;4-Phenyl-2-bromopyridine;2-BROMO-4-PHENYLPYRIDINE;2-bromo-4-phenyl-pyridin;2-bromine-4-phenylpyridine;Pyridine, 2-bromo-4-phenyl-;2-Bromo-4-phenylpyridine 97+%;(2-Bromo-pyridin-4-yl)benzene
- CBNumber
- CB6769945
- Molecular Formula
- C11H8BrN
- Formula Weight
- 234.09
- MOL File
- 54151-74-5.mol
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2-BROMO-4-PHENYLPYRIDINE Property
- Melting point:
- 65-66 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 311.7±22.0 °C(Predicted)
- Density
- 1.426±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 0.96±0.10(Predicted)
- form
- powder
- color
- Yellow
- InChI
- InChI=1S/C11H8BrN/c12-11-8-10(6-7-13-11)9-4-2-1-3-5-9/h1-8H
- InChIKey
- KRIILKQTJUOQCJ-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=CC(C2=CC=CC=C2)=C1
- EPA Substance Registry System
- 2-Bromo-4-phenylpyridine (54151-74-5)
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- FB142806
- Product name
- 2-Bromo-4-phenylpyridine
- Packaging
- 250mg
- Price
- $67.5
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB142806
- Product name
- 2-Bromo-4-phenylpyridine
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR9966
- Product name
- 2-Bromo-4-phenylpyridine
- Purity
- 97+%
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-9-U9
- Product name
- 2-Bromo-4-phenylpyridine
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB142806
- Product name
- 2-Bromo-4-phenylpyridine
- Packaging
- 1g
- Price
- $201
- Updated
- 2021/12/16
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2-BROMO-4-PHENYLPYRIDINE Chemical Properties,Usage,Production
Uses
2-Bromo-4-phenylpyridine is used as an intermediate in organic synthesis and pharmaceuticals.
Synthesis
939-23-1
54151-74-5
The general procedure for the synthesis of 2-bromo-4-phenylpyridine from 4-phenylpyridine was as follows: dimethylaminoethanol (DMAE, 1.50 mL, 15.0 mmol) was dissolved in hexane (20.0 mL) and stirred under cooling in an ice bath. Under the same cooling conditions, n-butyllithium (2.5 mol/L hexane solution, 12.0 mL, 30.0 mmol) was slowly added dropwise, followed by stirring the reaction mixture for 30 minutes. Keeping the ice bath cool, a hexane solution (30.0 mL) of 4-phenylpyridine (776 mg, 5.00 mmol) was slowly added and stirring was continued for 1 h under these conditions. The reaction system was cooled to -78°C, a hexane solution (15.0 mL) of carbon tetrafluoride (6.30 g, 18.0 mmol) was slowly added dropwise and stirred for 50 minutes. Upon completion of the reaction, deionized water was added under cooling in an ice bath to quench the reaction, followed by extraction with ethyl acetate (100 mL x 2). The organic layers were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography using ethyl acetate/hexane (1:4, v/v) as eluent to afford the target product 2-bromo-4-phenylpyridine (645 mg, 55.1% yield).
References
[1] Journal of Organic Chemistry, 2003, vol. 68, # 5, p. 2028 - 2029
[2] Patent: TW2016/39840, 2016, A. Location in patent: Paragraph 0020; 0040
[3] Patent: WO2007/20888, 2007, A1. Location in patent: Page/Page column 43
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 5842
2-BROMO-4-PHENYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-4-PHENYLPYRIDINE manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2-BROMO-4-PHENYLPYRIDINE 54151-74-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
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