Sutimlimab

Sutimlimab Property

storage temp. 

Store at -20°C

form 

Liquid

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Sutimlimab Chemical Properties,Usage,Production

Uses

Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase[1].

Biological Activity

Sutimlimab, a first-in-class humanized immunoglobulin G4 (IgG4) monoclonal antibody that selectively inhibits the classical complement pathway at C1s, rapidly halted hemolysis in the single-arm CARDINAL study in recently transfused patients with cold agglutinin disease (CAD).

References

[1] Alexander R?th, et al. Sutimlimab in Cold Agglutinin Disease. N Engl J Med. 2021 Apr 8;384(14):1323-1334. DOI:10.1056/NEJMoa2027760