Cemiplimab

Product Name: Cemiplimab
CAS No.: 1801342-60-8
Chemical Name: Cemiplimab
Synonyms: Cemiplimab;REGN-2810|||SAR-439684;Cemiplimab (anti-PD-1);Research Grade Cemiplimab;Research Grade Cemiplimab(DHH02201)
CBNumber: CB68081098
Formula Weight: 0
MOL File: Mol file

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Cemiplimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Cemiplimab Chemical Properties,Usage,Production

Uses

Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research[1][2].

in vivo

Cemiplimab (i.p., 10 mg/kg, five injections within 2 weeks) can increased the proportion of effector T cells in tumors and dLNs to reduce tumor growth by combined immunotherapy with REGN3767 in MC38.Ova tumor mice model^[2].

Animal Model:	Female human PD-1×LAG-3 knockin mice (8-10 weeks) with MC38.Ova cells^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; five injections within 2 weeks
Result:	Partially inhibited the growth of MC38.Ova tumors and prolonged the survival of mice by administering alone. Significantly increased the proportion of CD4⁺ TILs in IFNγ and TNFα by combined immunotherapy with REGN3767.

References

[1] Michael R Migden, et al. PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma. N Engl J Med. 2018 Jul 26;379(4):341-351. DOI:10.1056/NEJMoa1805131
[2] Elena Burova, et al. Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3-Knockin Mice. Mol Cancer Ther. 2019 Nov;18(11):2051-2062. DOI:10.1158/1535-7163.MCT-18-1376

Cemiplimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Cemiplimab Suppliers

China 21 United States 2 Global 23

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Cemiplimab

Research Grade Cemiplimab(DHH02201)

Cemiplimab (anti-PD-1)

REGN-2810|||SAR-439684

Research Grade Cemiplimab

1801342-60-8