2,4,6-Collidine
- Product Name
- 2,4,6-Collidine
- CAS No.
- 108-75-8
- Chemical Name
- 2,4,6-Collidine
- Synonyms
- 2,4,6-TRIMETHYLPYRIDINE;S-COLLIDINE;g-Collidine;2,4,6-Kollidin;246CO;246BD;2,4,6-CoL;SYM COLLIDINE;2,4,6-COLLIDINE;GAMMA-COLLIDINE
- CBNumber
- CB6852760
- Molecular Formula
- C8H11N
- Formula Weight
- 121.18
- MOL File
- 108-75-8.mol
2,4,6-Collidine Property
- Melting point:
- -43 °C (lit.)
- Boiling point:
- 171-172 °C (lit.)
- Density
- 0.917 g/mL at 25 °C (lit.)
- vapor pressure
- 4 hPa (20 °C)
- refractive index
- n20/D 1.498(lit.)
- Flash point:
- 135 °F
- storage temp.
- Store below +30°C.
- solubility
- 35g/l
- form
- Liquid
- pka
- 7.43(at 25℃)
- color
- Clear colorless to yellow
- Water Solubility
- 35 g/L (20 ºC)
- Sensitive
- Hygroscopic
- Merck
- 14,9718
- BRN
- 107283
- Dielectric constant
- 1.9（20℃）
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- LogP
- 1.25 at 20℃
- CAS DataBase Reference
- 108-75-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2,4,6-trimethyl-(108-75-8)
- EPA Substance Registry System
- 2,4,6-Trimethylpyridine (108-75-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 10-20/21/22-36/37/38
- Safety Statements
- 26-36/37-36
- RIDADR
- UN 1992 3/PG 3
- WGK Germany
- 3
- RTECS
- UU0970000
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29333999
- Hazardous Substances Data
- 108-75-8(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 400 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.22267
- Product name
- 2,4,6-Trimethylpyridine
- Purity
- for synthesis
- Packaging
- 50mL
- Price
- $53
- Updated
- 2024/03/01
- Product number
- 8.22267
- Product name
- 2,4,6-Trimethylpyridine
- Purity
- for synthesis
- Packaging
- 250ML
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 8.22267
- Product name
- 2,4,6-Trimethylpyridine
- Purity
- for synthesis
- Packaging
- 1L
- Price
- $429
- Updated
- 2024/03/01
- Product number
- 142387
- Product name
- 2,4,6-Trimethylpyridine
- Purity
- ReagentPlus , 99%
- Packaging
- 5ml
- Price
- $29.2
- Updated
- 2024/03/01
- Product number
- 142387
- Product name
- 2,4,6-Trimethylpyridine
- Purity
- ReagentPlus , 99%
- Packaging
- 1l
- Price
- $832
- Updated
- 2024/03/01
2,4,6-Collidine Chemical Properties,Usage,Production
Chemical Properties
colourless liquid
Uses
2,4,6-Collidine is used as a tissue fixative for electron microscopy. It is useful in dehydrohalogenation reactions and acts as a solvent for the cleavage of hindered esters by anhydrous lithium iodide.
Uses
2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.
Definition
Methyl, ethyl, propyl, and trimethyl homologs of pyridine.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 4184, 1950 DOI: 10.1021/ja01165a097
General Description
2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.
Hazard
Toxic.
Flammability and Explosibility
Flammable
Purification Methods
Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]
2,4,6-Collidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-Collidine manufacturers
- Product
- 2,4,6-Collidine 108-75-8
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08
- Product
- 2,4,6-Collidine 108-75-8
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 10 TONS/Month
- Release date
- 2021-06-25
- Product
- 2,4,6-Collidine 108-75-8
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-04-29