1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- Product Name
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- CAS No.
- 61338-13-4
- Chemical Name
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- Synonyms
- Mirtazapine acid;Mirtazapine Impurity 7;Mirtazapine Carboxylic Acid;1-(3-carboxy-2-pyridyl)-4-methyl-2-phenylpiperazine;1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine;1-(3-Carboxypyrid-2-Yl)-2-Phenyl-4-Methyl-Piperazine (N-1);1-(3-CARBOXYL PYRIDYL-2)-PHENYL-4 METHYL PIPERAZINE (HMA);2-(4-Methyl-2-phenylpiperazin-1-yl)pyridine-3-carboxylic Acid;2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-(4-methyl-2-phenyl-1-piperazinyl)-
- CBNumber
- CB6855145
- Molecular Formula
- C17H19N3O2
- Formula Weight
- 297.35
- MOL File
- 61338-13-4.mol
1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine Property
- Melting point:
- 160-161 °C
- Boiling point:
- 494.3±45.0 °C(Predicted)
- Density
- 1.225
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.83±0.36(Predicted)
- form
- Solid
- color
- Light Tan
- Stability:
- Light Sensitive
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR17666
- Product name
- 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 4H58-1-KE
- Product name
- 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- R482
- Product name
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- Packaging
- 100mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- FC76353
- Product name
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC76353
- Product name
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine Chemical Properties,Usage,Production
Chemical Properties
Dark Yellow Solid
Uses
Mirtazapine (M365000) impurity.
Synthesis
61337-88-0
61338-13-4
Example 5: Preparation of 1-(3-carboxypyridin-2-yl)-4-methyl-2-phenylpiperazine Potassium hydroxide (150 g, flakes, 85% purity) was added to 1-(3-cyanopyridin-2-yl)-4-methyl-2-phenylpiperazine (54 g) with 75 mL of water and 6.5 g of dimethylsulfoxide (DMSO). The reaction mixture was heated to 145-150 °C and the reaction was stirred at this temperature for 8 hours. Upon completion of the reaction, the inorganic phase containing water and potassium hydroxide was separated and the organic phase containing mainly product oil was cooled. Subsequently, fresh water and toluene were added to the system to separate the two phases. The aqueous phase was neutralized with hydrochloric acid (HCl) to pH=6.5-7. The aqueous phase was evaporated and toluene was added under pH=6.5-7 conditions. The inorganic salt was removed by filtration and the toluene solution was evaporated to dryness to give 52 g of 1-(3-carboxypyridin-2-yl)-4-methyl-2-phenylpiperazine in 90% yield.
References
[1] Patent: US2003/69417, 2003, A1
[2] Patent: US2001/51718, 2001, A1
[3] Patent: US2003/69417, 2003, A1
[4] Patent: US2001/51718, 2001, A1
[5] Patent: JP2017/218411, 2017, A. Location in patent: Paragraph 0006; 0084; 0085
1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine manufacturers
- Product
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine 61338-13-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine 61338-13-4
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10
- Product
- 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine 61338-13-4
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10