ChemicalBook > CAS DataBase List > 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

Product Name
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
CAS No.
6713-54-8
Chemical Name
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
Synonyms
Nsc20089;Homouric;tetratomic;homouric acid;Dipyridamole Impurity 8;2,6,8,10-Tetrahydroxy-homopurine;Pyrimido[5,4-d]Pyrimidine Impurity 1;Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol;pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol;pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol
CBNumber
CB6875585
Molecular Formula
C6H4N4O4
Formula Weight
196.12
MOL File
6713-54-8.mol
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2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Property

Density 
1.89±0.1 g/cm3(Predicted)
pka
5.90±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T796778
Product name
2,4,6,8-Tetrahydroxypyrimido[5,4-d]pyrimidine
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
073607
Product name
2,4,6,8-Tetrahydroxypyrimido[5,4-d]pyrimidine
Purity
95+%
Packaging
5g
Price
$55
Updated
2021/12/16
AK Scientific
Product number
W7772
Product name
2,4,6,8-Tetrahydroxypyrimido-[5,4-d]pyrimidine
Packaging
100mg
Price
$39
Updated
2021/12/16
AK Scientific
Product number
W7772
Product name
2,4,6,8-Tetrahydroxypyrimido-[5,4-d]pyrimidine
Packaging
1g
Price
$156
Updated
2021/12/16
Matrix Scientific
Product number
073607
Product name
2,4,6,8-Tetrahydroxypyrimido[5,4-d]pyrimidine
Purity
95+%
Packaging
25g
Price
$180
Updated
2021/12/16
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2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Chemical Properties,Usage,Production

Uses

2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.

Synthesis

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Preparation Products And Raw materials

Raw materials

5-AMINOOROTIC ACID Urea

Preparation Products

2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
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View Lastest Price from 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine manufacturers

Career Henan Chemical Co
Product
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine 6713-54-8
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

6713-54-8, 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)PyrimidineRelated Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Dipyridamole Mono-O-b-D-glucuronide Dipyridamole 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol 2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol (DipyridaMole IMpurity) Dipyridamole Tripiperidine Dipyridamole Tri(diethanolamine) 6-Des(diethanolamino)-6-chloro Dipyridamole 4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine Desethanol Dipyridamole Pyrimido[5,4-d]pyrimidin-4-ol (8CI) 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

  • 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)tetrone
  • 2,6,8,10-Tetrahydroxy-homopurine
  • 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • 1H,2H,3H,4H,5H,6H,7H,8H-[1,3]DIAZINO[5,4-D]PYRIMIDINE-2,4,6,8-TETRONE
  • Homouric
  • homouric acid
  • 1,2,3,4,5,6,7,8-Octahydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8(1H,3H,5H,7H)-tetrone
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol
  • Nsc20089
  • pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol
  • pyriMido[5,4-d]pyriMidine-2,4,6,8(1H,3H,5H,7H)-tetraone
  • pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol
  • 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone
  • ,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • Dipyridamole Impurity 8
  • Pyrimido[5,4-d]Pyrimidine Impurity 1
  • 2,4,6,8-TETRAHYDROXYPYRIMIDO-[5,4-D]PYRIMIDIN
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)-tetrone, 1,5-dihydro-
  • 2,4,6,8-Tetrahydroxy-pynmido[5,4-d]pynmidine
  • tetratomic
  • 6713-54-8 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • 2,4,6, 8-tetrahydroxy pyrimidine and [5, 4-D] pyrimidine
  • 6713-54-8
  • Heterocycle-Pyrimidine series