methyl D-prolinate

Product Name: methyl D-prolinate
CAS No.: 43041-12-9
Chemical Name: methyl D-prolinate
Synonyms: Proline Impurity 1;methyl D-prolinate
CBNumber: CB6926586
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 43041-12-9.mol

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methyl D-prolinate Property

Boiling point:: 169.9±33.0 °C(Predicted)
Density: 1.055±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 8.23±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: AAA0004589
Product name: (R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $504
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004589
Product name: (R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $588
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 52836
Product name: D-ProlineMethylEster
Packaging: 10g
Price: $1250
Updated: 2021/12/16

Ambeed

Product number: A747545
Product name: (R)-Methylpyrrolidine-2-carboxylate
Purity: 95%
Packaging: 100mg
Price: $46
Updated: 2021/12/16

Ambeed

Product number: A747545
Product name: (R)-Methylpyrrolidine-2-carboxylate
Purity: 95%
Packaging: 250mg
Price: $77
Updated: 2021/12/16

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methyl D-prolinate Chemical Properties,Usage,Production

Uses

D-Proline Methyl Ester, is a building block used for the synthesis of pharmaceutical compounds, such as Eletriptan (E505000) acting as an Antimigrene.

Synthesis

67-56-1

609-36-9

43041-12-9

Thionyl chloride (0.75 mL, 10.43 mmol) was slowly added to a stirred solution of DL-proline (1 g, 8.69 mmol) in methanol (10 mL). The reaction mixture was heated to reflux temperature and stirred continuously for 16 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in dichloromethane (15 mL). Solid sodium bicarbonate was added to quench the excess thionyl chloride, and after filtration, the filtrate was concentrated under reduced pressure to afford methyl (R)-pyrrolidine-2-carboxylate (1.1 g, 98% yield) as a pale yellow solid.

References

[1] Patent: WO2018/20004, 2018, A1. Location in patent: Page/Page column 57
[2] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00143
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 16, p. 5616 - 5624
[4] Chemistry Letters, 1982, p. 745 - 748
[5] Journal of Agricultural and Food Chemistry, 1993, vol. 41, # 9, p. 1458 - 1461

methyl D-prolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl D-prolinate Suppliers

China 33 India 1 United States 2 Global 36

J & K SCIENTIFIC LTD.

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methyl D-prolinate

Proline Impurity 1

43041-12-9