methyl D-prolinate
- Product Name
- methyl D-prolinate
- CAS No.
- 43041-12-9
- Chemical Name
- methyl D-prolinate
- Synonyms
- Proline Impurity 1;methyl D-prolinate
- CBNumber
- CB6926586
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 43041-12-9.mol
methyl D-prolinate Property
- Boiling point:
- 169.9±33.0 °C(Predicted)
- Density
- 1.055±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.23±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AAA0004589
- Product name
- (R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504
- Updated
- 2021/12/16
- Product number
- AAA0004589
- Product name
- (R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 52836
- Product name
- D-ProlineMethylEster
- Packaging
- 10g
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- A747545
- Product name
- (R)-Methylpyrrolidine-2-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $46
- Updated
- 2021/12/16
- Product number
- A747545
- Product name
- (R)-Methylpyrrolidine-2-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $77
- Updated
- 2021/12/16
methyl D-prolinate Chemical Properties,Usage,Production
Uses
D-Proline Methyl Ester, is a building block used for the synthesis of pharmaceutical compounds, such as Eletriptan (E505000) acting as an Antimigrene.
Synthesis
67-56-1
609-36-9
43041-12-9
Thionyl chloride (0.75 mL, 10.43 mmol) was slowly added to a stirred solution of DL-proline (1 g, 8.69 mmol) in methanol (10 mL). The reaction mixture was heated to reflux temperature and stirred continuously for 16 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in dichloromethane (15 mL). Solid sodium bicarbonate was added to quench the excess thionyl chloride, and after filtration, the filtrate was concentrated under reduced pressure to afford methyl (R)-pyrrolidine-2-carboxylate (1.1 g, 98% yield) as a pale yellow solid.
References
[1] Patent: WO2018/20004, 2018, A1. Location in patent: Page/Page column 57
[2] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00143
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 16, p. 5616 - 5624
[4] Chemistry Letters, 1982, p. 745 - 748
[5] Journal of Agricultural and Food Chemistry, 1993, vol. 41, # 9, p. 1458 - 1461
methyl D-prolinate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl D-prolinate Suppliers
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