ChemicalBook > CAS DataBase List > 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)

5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)

Product Name: 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)
CAS No.: 20090-69-1
Chemical Name: 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)
Synonyms: NSC 243816;2-Chloro-4-MethylpyriMidin-5-aMine;5-Amino-2-chloro-4-methylpyrimidine;5-PyriMidinaMine, 2-chloro-4-Methyl-;2-chloro-4-methyl-pyrimidin-5-ylamine;5-Pyrimidinamine, 2-chloro-4-methyl- (9CI);5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) ISO 9001：2015 REACH
CBNumber: CB71082097
Molecular Formula: C5H6ClN3
Formula Weight: 143.57
MOL File: 20090-69-1.mol

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5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Property

Melting point:: 93.5℃
Boiling point:: 309.4±22.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.36±0.29(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C5H6ClN3/c1-3-4(7)2-8-5(6)9-3/h2H,7H2,1H3
InChIKey: RZAKVHVZRSQZEQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(N)C(C)=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H331Toxic if inhaled

H401Toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A595670
Product name: 5-Amino-2-chloro-4-methylpyrimidine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC153804
Product name: 2-Chloro-4-methylpyrimidin-5-amine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W4245
Product name: 2-Chloro-4-methylpyrimidin-5-amine
Packaging: 250mg
Price: $119
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC153804
Product name: 2-Chloro-4-methylpyrimidin-5-amine
Packaging: 500mg
Price: $190
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC153804
Product name: 2-Chloro-4-methylpyrimidin-5-amine
Packaging: 1g
Price: $332.5
Updated: 2021/12/16

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5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Chemical Properties,Usage,Production

Synthesis

13162-26-0

20090-69-1

The general procedure for the synthesis of 5-amino-2-chloro-4-methylpyrimidine from 2,4-dichloro-5-nitro-6-methylpyrimidine was as follows: to a stirred methanol (100 mL) solution of 2,4-dichloro-6-methyl-5-nitropyrimidine (10 g, 48.1 mmol) and ammonium chloride (25.7 g, 481 mmol) under nitrogen protection was added in batches zinc powder ( 31.4 g, 481 mmol). The reaction mixture was stirred at 70 °C for 50 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 30:1). All fractions containing the target product were collected and detected by thin layer chromatography (unfolding agent: ethyl acetate/petroleum ether, 1:1, Rf=0.6), combined and concentrated to give 2-chloro-4-methylpyrimidin-5-amine (2 g, 13.93 mmol, 29.0% yield) as a light yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.95 (s, 1H), 3.66 (s, 2H), 2.88 (s, 3H); ESI-MS m/z: 144.2 ([M+H]+).

References

[1] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 138
[2] Chemische Berichte, 1901, vol. 34, p. 1242
[3] Yakugaku Zasshi, 1942, vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
[4] Chem.Abstr., 1951, p. 5150
[5] Patent: EP2100894, 2009, A1. Location in patent: Page/Page column 20

5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) manufacturers

Dideu Industries Group Limited

Product: 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) 20090-69-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-07

Career Henan Chemical Co

Product: 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) 20090-69-1
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

20090-69-1, 5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)Related Search:

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5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)

5-Amino-2-chloro-4-methylpyrimidine

2-chloro-4-methyl-pyrimidin-5-ylamine

2-Chloro-4-MethylpyriMidin-5-aMine

NSC 243816

5-PyriMidinaMine, 2-chloro-4-Methyl-

5-Pyrimidinamine, 2-chloro-4-methyl- (9CI) ISO 9001：2015 REACH

20090-69-1

PYRIMIDINE