ChemicalBook > CAS DataBase List > 2-CHLORO-3-IODOPHENOL

2-CHLORO-3-IODOPHENOL

Product Name: 2-CHLORO-3-IODOPHENOL
CAS No.: 666727-31-7
Chemical Name: 2-CHLORO-3-IODOPHENOL
Synonyms: 2-CHLORO-3-IODOPHENOL;Phenol, 2-chloro-3-iodo-
CBNumber: CB7110915
Molecular Formula: C6H4ClIO
Formula Weight: 254.45
MOL File: 666727-31-7.mol

Less

2-CHLORO-3-IODOPHENOL Property

storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Appearance: Light brown to brown Solid

Less

Safety

HS Code: 2908190090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0041409
Product name: 2-Chloro-3-iodophenol
Purity: >97.0%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 0239AC
Product name: 2-Chloro-3-iodophenol
Packaging: 250mg
Price: $212
Updated: 2021/12/16

AK Scientific

Product number: 0239AC
Product name: 2-Chloro-3-iodophenol
Packaging: 100mg
Price: $151
Updated: 2021/12/16

ChemScene

Product number: CS-0041409
Product name: 2-Chloro-3-iodophenol
Purity: >97.0%
Packaging: 1g
Price: $194
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011413
Product name: 2-CHLORO-3-IODOPHENOL
Purity: 95.00%
Packaging: 5MG
Price: $502.9
Updated: 2021/12/16

Less

2-CHLORO-3-IODOPHENOL Chemical Properties,Usage,Production

Synthesis

56962-01-7

666727-31-7

The general procedure for the synthesis of 2-chloro-3-iodophenol from 3-amino-2-chlorophenol is as follows: 1. To a suspension of 2-amino-3-nitrophenol (10 g, 65 mmol) in concentrated hydrochloric acid (10 mL) was added dropwise an aqueous solution of sodium nitrite (5.1 g, 73.3 mmol) (60 mL) at 0 °C. After stirring for 30 min, 10% H2SO4 solution (3 mL) of CuCl (12.8 g, 130 mmol) was added and stirring was continued for 18 hours. The reaction mixture was filtered, washed with water and the filtrate was extracted with EtOAc (70 mL x 3). The EtOAc layer was concentrated to give 2-chloro-3-nitrophenol (7 g, 62% yield). 2. 2-Chloro-3-nitrophenol (6 g, 35 mmol) was dissolved in methanol (100 mL), ammonium chloride (9.4 g, 175.7 mmol) and zinc powder (46 g, 702.8 mmol) were added, and refluxed for 1 hour. It was filtered and concentrated to give 2-chloro-3-aminophenol (4.5 g, 90% yield) as a purple solid. 3. To a suspension of 2-chloro-3-aminophenol (4.5 g, 31 mmol) in concentrated hydrochloric acid (10 mL) was added an aqueous solution of sodium nitrite (2.5 g, 35 mmol) (50 mL) dropwise at 0 °C. After stirring for 30 min, 10% H2SO4 solution (3 mL) of iodine (10.4 g, 63 mmol) was added and stirred for 2 h at room temperature. After filtration, it was extracted with EtOAc and concentrated to give 2-chloro-3-iodophenol (6 g, 75% yield) as a dark purple solid. 4. 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline (2.3 g, 9.2 mmol) was mixed with bis(pinacolato)diborane (4.2 g, 16.5 mmol) in DMSO (2 mL) and KOAc (2.7 g, 27.4 mmol) and PdCl2 (dppf) (100 mg) were added. The reaction was carried out at 120°C for 15 min in microwave, cooled and purified by chromatography to afford 2,2,4-trimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydroquinoline (2.3 g, 84% yield) as a white crystalline solid. 5. 2,2,4-Trimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydroquinoline (308 mg), 2-chloro-3-iodophenol (93 mg), PdCl2 (dppf) (100 mg) and KOAc (300 mg) were coupled to give 2-chloro-3-(2,2,4-trimethyl-1 ,2-dihydroquinolin-6-yl)phenol (85 mg). 6. The above product (85 mg) was reacted with NBS according to the method of Example 7 to obtain 3-(4-bromomethyl-2,2-dimethyl-1,2-dihydroquinolin-6-yl)-2-chlorophenol (56 mg). 7. Finally, the product (50 mg) was coupled with 2-phenylethanethiol (0.04 mL) to give the title compound (40 mg) as an oil.

References

[1] Patent: WO2004/18429, 2004, A2. Location in patent: Page 87

2-CHLORO-3-IODOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-CHLORO-3-IODOPHENOL Suppliers

China 43 India 1 United Kingdom 1 United States 5 Global 50

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Xinyanhe Pharmatech Co.,Ltd

Tel: 0519-85252752 15366845260
Fax: 86-0519-85683352
Email: taihuaren@vip.163.com
Country: China
ProdList: 1124
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9405
Advantage: 55

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9996
Advantage: 55

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Henan's chemical products co., LTD

Tel: 0371-60919097 15378766539
Fax: 0371-60919097
Email: 794449696@qq.com
Country: China
ProdList: 4996
Advantage: 58

Shanghai silk sail pharmaceutical technology co., LTD

Tel: 18916696128
Email: service@snowpharm.com
Country: China
ProdList: 1369
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Xinyi Kaiwu Chemical Technology Co., Ltd.

Tel: 0516-0516-88997009 18651776937
Email: 4164357@qq.com
Country: China
ProdList: 3204
Advantage: 58

Changzhou Ansciep Chemical Co., Ltd.

Tel: 0519-86305871 13961213398
Email: tina@ansciepchem.com
Country: China
ProdList: 1701
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Jinan ponder chemical co. LTD

Tel: 0531-0000
Email: thinklifescience@163.com
Country: China
ProdList: 19689
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Encyclopedia Source (Chengdu) Technology Co., Ltd.

Tel: 15021461747
Email: 446211270@qq.com
Country: China
ProdList: 1196
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Anhui Henuo Biotechnology Co., Ltd

Tel: 18455579438
Country: China
ProdList: 16684
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Tel: 400-0628126 18736790110;
Email: sales-team@aobchem.com.cn
Country: China
ProdList: 50000
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: syeu@accelachem.com
Country: China
ProdList: 11015
Advantage: 58

Zhengzhou JACS Chemical Product Co., LTD

Tel: 0371-86259281 13223061139
Email: 893596907@qq.com
Country: China
ProdList: 7993
Advantage: 58

BEIJINGYIWANJINGRUI

Tel: 15866847540
Email: dengyt2000@163.com
Country: China
ProdList: 4100
Advantage: 58

Hunan Hui Bai Yi New Materials Co., Ltd

Tel: 0745-2866551 19976851779
Email: 3002713163@qq.com
Country: China
ProdList: 7333
Advantage: 58

Zhengzhou Haochuang New Material Co., Ltd.

Tel: 19139721821
Email: 3545426645@qq.com
Country: China
ProdList: 4989
Advantage: 58

Shanghai Fengluan Biotechnology Co., LTD

Tel: 13357659136
Email: jing.z@fengluanbiotech.com
Country: China
ProdList: 500
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Nanjing Fred Technology Co., Ltd

Tel: +86-25-84696168 +86-15380713688
Email: Austin@fredbio.com
Country: China
ProdList: 2428
Advantage: 58

Guangzhou Weike Biotechnology Co., Ltd.

Tel: 15902098758
Country: CHINA
ProdList: 133
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Guangzhou Chengguo Biological Co., Ltd.

Tel: 14743339820
Country: CHINA
ProdList: 181
Advantage: 58

Shanghai Fchemicals Technology Co., Ltd

Tel: --
Fax: --
Email: hqliang@fchemicals.com
Country: China
ProdList: 4375
Advantage: 47

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

666727-31-7, 2-CHLORO-3-IODOPHENOLRelated Search:

TETRACHLOROGUAJACOL 3-Iodophenol 4-CHLORO-2-IODOPHENOL 2-({[3-(1,3-benzoxazol-2-yl)-4-chlorophenyl]imino}methyl)-4-chloro-6-iodophenol 3-CHLORO-2-IODOPHENOL 5-CHLORO-2-IODOPHENOL 2-CHLORO-5-IODOPHENOL 2-({[4-(1,3-benzoxazol-2-yl)-3-hydroxyphenyl]imino}methyl)-4-chloro-6-iodophenol 2-({[2-(4-tert-butylphenyl)-1,3-benzoxazol-5-yl]imino}methyl)-4-chloro-6-iodophenol 4-CHLORO-3-IODOPHENOL 2-CHLORO-3-IODOPHENYL N,N-DIETHYLCARBAMATE 2-CHLORO-3-IODOPHENOL

2-CHLORO-3-IODOPHENOL

Phenol, 2-chloro-3-iodo-

666727-31-7

C6H4ClIO

pharmacetical