Valspodar

Product Name: Valspodar
CAS No.: 121584-18-7
Chemical Name: Valspodar
Synonyms: Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber: CB71116624
Molecular Formula: C63H111N11O12
Formula Weight: 1214.62
MOL File: 121584-18-7.mol

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Valspodar Property

Melting point:: 143-145°C
Boiling point:: 1290.1±65.0 °C(Predicted)
alpha: D20 -255.1° (c = 0.5 in CHCl3)
Density: 1.015±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.45±0.70(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $184
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $723
Updated: 2023/01/07

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 500μg
Price: $25
Updated: 2023/01/06

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 1mg
Price: $48
Updated: 2023/01/06

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 5 mg
Price: $163
Updated: 2023/01/06

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Valspodar Chemical Properties,Usage,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [¹⁴C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Antineoplastic adjunct (chemosensitizer).

Definition

ChEBI: SDZ PSC 833 is a homodetic cyclic peptide.

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

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Valspodar Suppliers

Canada 1 China 90 India 3 Japan 1 United Kingdom 4 United States 17 Global 116

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Email: sales@lollanechem.com
Country: China
ProdList: 3658
Advantage: 55

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3463
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15861
Advantage: 69

Alabiochem Tech.Co., Ltd.

Tel: 0512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 992
Advantage: 59

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6001
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai SynFarm Pharmaceutical Technology Co., Ltd.

Tel: 021-50793966 18917198199
Fax: +86-21-50793967
Email: info@synfarm.com
Country: China
ProdList: 276
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

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View Lastest Price from Valspodar manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

121584-18-7, ValspodarRelated Search:

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Valspodar

3'-Keto-bmt(1)-Val(2)-cyclosporin a

Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-

Psc 833

Sdz psc 833

Sdz-psc-833

Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA

Valspodar(PSC-833,AMdray)

6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D

6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A

AMdray

Valpodar

PSC833(Valspodar)

Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-

Valspodar (PSC-833)

[3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D

PSC833 - Specific MDR1/P-gp Inhibitor

Valspodar, >=98%

CS-51

PSC 833; PSC-833; PSC833

121584-18-7

Intermediates & Fine Chemicals

Peptides

Pharmaceuticals