Anidulafungin
- Product Name
- Anidulafungin
- CAS No.
- 166663-25-8
- Chemical Name
- Anidulafungin
- Synonyms
- Eraxis;Ecalta;CS-2272;LY 303366;nidulafungin;AN(Local GMP);Anidulafungin;Arnie Finn net;LY 303366, Eraxis;Anidulafungin-d11
- CBNumber
- CB71120054
- Molecular Formula
- C58H73N7O17
- Formula Weight
- 1140.24
- MOL File
- 166663-25-8.mol
Anidulafungin Property
- Melting point:
- >196°C (subl.)
- Boiling point:
- 1477.0±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 9.86±0.26(Predicted)
- form
- Solid
- color
- White to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20753
- Product name
- Anidulafungin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20753
- Product name
- Anidulafungin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 20753
- Product name
- Anidulafungin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 20753
- Product name
- Anidulafungin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 441586
- Product name
- Anidulafungin-d11
- Packaging
- 500ug
- Price
- $502
- Updated
- 2021/12/16
Anidulafungin Chemical Properties,Usage,Production
Description
Anidulafungin, a semi-synthetic derivative of echinocandin B, has been developed and launched as an intravenous treatment for serious fungal infections, such as candidemia, Candida-derived peritonitis, intra-abdominal abscesses, and esophageal candidiasis. As a non-competitive inhibitor of 1,3-b-D-glucan synthase, which is responsible for the formation of glucan polymers, anidulafungin interferes with the cell wall synthesis of most pathogenic fungi. This mode of action is characteristic of the echinocandin class of antifungals. While the first member of this class, cilofungin, was withdrawn due to toxicity associated with the formulation vehicle, anidulafungin follows the successful introduction of caspofungin and micafungin. Compared to the other echinocandins, anidulafungin appears to be more potent (MIC90 ofr0.25 mg/mL for C.albicans, 0.5 mg/mL for C.glabrata, 1 mg/mL for C. krusel and C.tropicalis, 2mg/mL for C.lusitaniae, and 2 mg/mL for Aspergillus spp) and is devoid of significant drug interactions since it is neither an inhibitor nor substrate of the cytochrome P450 isoenzymes. The emergence of the echinocandins circumvents the concern regarding the rising resistance to the azole and amphotericin B antifungals; no cross-resistance is expected because the echinocandins work at the cell wall rather than the cell membrane.
Originator
Eli Lilly (US)
Uses
nucleoside reverse transcriptase inhibitor (NRTI) for HIV treatment in adults
Uses
Anidulafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1995 and commercially developed by Eli Lilly. Anidulafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 400 citations.
Definition
ChEBI: A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.
brand name
Eraxis (Vicuron).
Antimicrobial activity
It is active against Aspergillus spp., Candida spp. and the cyst stage of Pneumocystis jirovecii. Resistance has not yet been reported.
Pharmaceutical Applications
A semisynthetic lipopeptide derived from a fermentation product of Aspergillus nidulans. Formulated for intravenous infusion.
Pharmacokinetics
Cmax 100 mg 1-h infusion: c. 9 mg/L end infusion
Plasma half-life: 18–27 h
Volume of distribution: 0.6 L/kg
Plasma protein binding: 84%
Blood concentrations increase in proportion to dosage. The
steady state is achieved on the first day after a loading dose
(twice the daily maintenance dose).
Distribution
Levels in the CSF are negligible.
Metabolism and excretion
Unlike caspofungin and micafungin, anidulafungin is not metabolized by the liver, but undergoes slow non-enzymatic degradation in the blood to a peptide breakdown product which is enzymatically degraded and excreted in the feces and bile. About 30% of a dose is eliminated in the feces, of which less than 10% is unchanged drug. Less than 1% of a dose is excreted in the urine. No dosage adjustment is required in patients with hepatic or renal impairment. Anidulafungin is not cleared by hemodialysis.
Clinical Use
Candidemia and certain invasive forms of candidosis
Esophageal candidosis
Side effects
Occasional histamine-mediated infusion-related reactions, injection site reactions and transient abnormalities of liver enzymes have been reported.
Metabolism
Hepatic metabolism of anidulafungin has not been
observed. Anidulafungin is not a clinically relevant
substrate, inducer, or inhibitor of cytochrome P450
isoenzymes.
Anidulafungin undergoes slow chemical degradation at
physiologic temperature and pH to a ring-opened peptide
that lacks antifungal activity. The ring-opened product
is subsequently converted to peptidic degradants and
eliminated mainly through biliary excretion.
In a single-dose clinical study, radiolabelled
[14C]-anidulafungin (~88 mg) was administered to
healthy subjects. Approximately 30% of the administered
radioactive dose was eliminated in the faeces over 9 days,
of which less than 10% was intact drug. Less than 1%
of the administered radioactive dose was excreted in the
urine, indicating negligible renal clearance.
References
[1] zhanel gg1, karlowsky ja, harding ga, balko tv, zelenitsky sa, friesen m, kabani a, turik m, hoban dj. in vitro activity of a new semisynthetic echinocandin, ly-303366, against systemic isolates of candida species, cryptococcus neoformans, blastomyces dermatitidis, and aspergillus species. antimicrob agents chemother. 1997 apr;41(4):863-5.
Anidulafungin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Anidulafungin manufacturers
- Product
- Anidulafungin 166663-25-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000kg/month
- Release date
- 2021-07-27
- Product
- Anidulafungin 166663-25-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 1kg
- Release date
- 2023-08-02
- Product
- Anidulafungin 166663-25-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05