Naltrexone hydrochloride

Product Name: Naltrexone hydrochloride
CAS No.: 16676-29-2
Chemical Name: Naltrexone hydrochloride
Synonyms: ReVia;Depade;nih8503;en1639a;Nalorex;Antaxone;4-D-butyl;Ccris 1168;NSC 409767;Nalmefene-3
CBNumber: CB7121465
Molecular Formula: C20H24ClNO4
Formula Weight: 377.87
MOL File: 16676-29-2.mol

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Naltrexone hydrochloride Property

Melting point:: 274-2760C
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
color: White to Off-White
Water Solubility: Soluble in water at 50mg/ml.
Sensitive: Light Sensitive
Merck: 13,6389
BRN: 3580333
CAS DataBase Reference: 16676-29-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-36
WGK Germany: 3
RTECS: QD2160000
F: 8-10
HS Code: 2932.99.7000
Toxicity: guinea pig,LD50,oral,1490mg/kg (1490mg/kg),Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N3136
Product name: Naltrexone hydrochloride
Packaging: 100mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: N3136
Product name: Naltrexone hydrochloride
Packaging: 1g
Price: $633
Updated: 2024/03/01

TCI Chemical

Product number: N1176
Product name: Naltrexone Hydrochloride
Packaging: 250MG
Price: $145
Updated: 2024/03/01

TCI Chemical

Product number: N1176
Product name: Naltrexone Hydrochloride
Packaging: 1G
Price: $433
Updated: 2024/03/01

Alfa Aesar

Product number: J60590
Product name: Naltrexone hydrochloride
Packaging: 250mg
Price: $155
Updated: 2023/06/20

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Naltrexone hydrochloride Chemical Properties,Usage,Production

Description

Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.

Chemical Properties

White Crystalline Powder

Originator

Endo (USA)

Uses

Nonselective opioid receptor antagonist; congener of naloxone

Uses

Naltrexone hydrochloride has been used:
as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22.

Uses

sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent

Uses

Narcotic antagonist, In treatment of?alcoholism

Definition

ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+).

brand name

TREXAN

Biological Activity

Opioid antagonist.

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Clinical Use

Opioid antagonist:
Adjunctive prophylactic treatment in patient’s previously opioid dependant
Treatment of alcohol dependence

Drug interactions

Potentially hazardous interactions with other drugs
Opioids: Avoid concomitant use.

Metabolism

Naltrexone is well absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism and may undergo enterohepatic recycling. It is extensively metabolised in the liver and the major metabolite, 6-β-naltrexol, may also possess weak opioid antagonist activity. It is excreted mainly in the urine, <5% is excreted in the faeces. The renal clearance for naltrexone ranges from 30-127 mL/min and suggests that renal elimination is primarily by glomerular filtration

storage

Room temperature

Purification Methods

This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]

Naltrexone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Naltrexone hydrochloride Suppliers

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View Lastest Price from Naltrexone hydrochloride manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: Naltrexone hydrochloride 16676-29-2
Price: US $50.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-21

Shaanxi Dideu Medichem Co. Ltd

Product: Naltrexone hydrochloride 16676-29-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Henan Bao Enluo International TradeCo.，LTD

Product: Naltrexone hydrochloride 16676-29-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-07-21

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Nalmefene Impurity C

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(5α)-17-(Cyclopropyl-Methyl-d3)-4,5-epoxy-3,14-dihydroxyMorphinan-6-one Hydrochloride

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(5-alpha)-id

HIC-A90670115

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4-D-butyl

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NSC 409767

Nalbuphine Impurity 5（Naltrexone hydrochloride、Nalfuranfine Impurity 8）

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16676-29-2

16676-29-3

C20H23NO4HCl

C20H23NO4ClH

C20H23NO4HClH2O

Biochemicals and Reagents

BioChemical