ChemicalBook > CAS DataBase List > 5-Phenylthiophene-2-carboxylic acid

5-Phenylthiophene-2-carboxylic acid

Uses

Product Name: 5-Phenylthiophene-2-carboxylic acid
CAS No.: 19163-24-7
Chemical Name: 5-Phenylthiophene-2-carboxylic acid
Synonyms: AKOS B029964;AKOS BAR-0576;BUTTPARK 98\04-16;RARECHEM AL BE 0489;5-Phenyl-2-thenoic Acid;2-Carboxy-5-phenylthiophene;5-phenyl-2-furancarbothioic S-acid;5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID;5-PHENYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-phenyl-
CBNumber: CB7123393
Molecular Formula: C11H8O2S
Formula Weight: 204.24
MOL File: 19163-24-7.mol

Less

5-Phenylthiophene-2-carboxylic acid Property

Melting point:: 186-190°C
Boiling point:: 393.6±30.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: powder to crystal
pka: 3.52±0.10(Predicted)
color: White to Orange to Green
λmax: 310nm(EtOH)(lit.)
CAS DataBase Reference: 19163-24-7(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
HazardClass: IRRITANT
HS Code: 2934999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L498998
Product name: 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $42.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: L498998
Product name: 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
Purity: AldrichCPR
Packaging: 250MG
Price: $41.5
Updated: 2024/03/01

TCI Chemical

Product number: P2347
Product name: 5-Phenyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 250mg
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: P2347
Product name: 5-Phenyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $149
Updated: 2025/07/31

TRC

Product number: P320933
Product name: 5-Phenylthiophene-2-carboxylicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Less

5-Phenylthiophene-2-carboxylic acid Chemical Properties,Usage,Production

Uses

Thiophene derivatives are widely used in the synthesis of pesticides, pharmaceuticals, chemical reagents, dyes, and polymer auxiliaries. 5-Phenylen-2-carboxylic acid has extensive applications in organic synthesis.

Definition

ChEBI: 5-Phenylthiophene-2-carboxylic acid is a thiophenecarboxylic acid.

Synthesis

14597-62-7

19163-24-7

GENERAL STEPS: To a mixed solution of methanol (5 mL) and tetrahydrofuran (5 mL) of 2-methoxycarbonyl-5-phenylthiophene (437 mg) was added 1 N aqueous sodium hydroxide (3 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, 1 N hydrochloric acid (5 mL) was slowly added to the reaction mixture for acidification. The precipitated solid was collected by filtration and washed with a small amount of cold water and dried under vacuum to give 5-phenylthiophene-2-carboxylic acid (397 mg, 97.1% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, δ): 7.3-7.5 (3H, m), 7.58 (1H, d, J = 3.9 Hz), 7.6-7.8 (3H, m), 13.15 (1H, wide s). Electrospray mass spectrometry (ESI-MS) showed m/z: 203 ([M-H]-).

References

[1] Patent: US6770667, 2004, B1. Location in patent: Page column 11
[2] ChemMedChem, 2011, vol. 6, # 2, p. 362 - 377
[3] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5536 - 5548

5-Phenylthiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Iodobenzene Palladium (II) Acetate Silver nitrate 2-Thiophenecarboxaldehyde N,N-Dimethylformamide Potassium hydroxide Cesium carbonate Triphenylphosphine

Preparation Products

Less

5-Phenylthiophene-2-carboxylic acid Suppliers

Belgium 1 China 96 Europe 1 Germany 6 India 4 Japan 1 Russia 1 The Netherlands 1 Ukraine 2 United Kingdom 7 United States 18 Global 138

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.

Tel: 02161555100
Fax: -
Country: China
ProdList: 820
Advantage: 58

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9519
Advantage: 55

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Nanjing Pope Bio-tech R&D Co., Ltd

Tel: 025-87138562
Email: sales@popebiotech.com
Country: China
ProdList: 413
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Baoyisheng Biotechnology Co., LTD

Tel: 15221020695
Email: 502277408@qq.com
Country: China
ProdList: 459
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
Advantage: 58

Xinyi Kaiwu Chemical Technology Co., Ltd.

Tel: 0516-0516-88997009 18651776937
Email: 4164357@qq.com
Country: China
ProdList: 3204
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Wuxi Kehua Biological Technology Co., Ltd.

Tel: 0510-86838766 13636419861
Email: 2258830676@qq.com
Country: China
ProdList: 5044
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9941
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

19163-24-7, 5-Phenylthiophene-2-carboxylic acidRelated Search:

Thifensulfuron methyl 3-Thiophenemalonic acid Tetrahydrothiophene Cephalothin sodium 2-Thiophenecarboxylic acid hydrazide Thifensulfuron EPA Dibenzothiophene 2-Thiophenecarboxylic acid POLYTHIOPHENE METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 3-AMINO-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID ,3-AMINO-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester ETHYL 3-AMINO-5-(4-NITROPHENYL)THIOPHEN& METHYL 3-AMINO-5-(4-ISOBUTYLPHENYL)THIOPHENE-2-CARBOXYLATE METHYL 8-CHLORO-4H-BENZO[B]THIENO[2,3-D]THIINE-2-CARBOXYLATE

BUTTPARK 98\04-16

JR-6467, 5-Phenylthiophene-2-carboxylic acid, 97%

5-phenyl-2-furancarbothioic S-acid

AKOS B029964

AKOS BAR-0576

5-PHENYL-2-THIOPHENECARBOXYLIC ACID

5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID

RARECHEM AL BE 0489

2-Carboxy-5-phenylthiophene

2-Carboxy-5-phenylthiophene, 5-Phenyl-2-thenoic acid

5-Phenylthiophene-2-carboxylic acid, 95+%

2-Thiophenecarboxylic acid, 5-phenyl-

5-Phenyl-2-thenoic Acid

19163-24-7

API intermediates

Acids and Derivatives

Heterocycles