Pseudouridine

Product Name: Pseudouridine
CAS No.: 1445-07-4
Chemical Name: Pseudouridine
Synonyms: PSEUDOURIDINE;Pseudo-UTP;5-Ribosyluracil;β-Pseudouridine;5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;y-Uridine;NSC 162405;Pseudoruidine;Pseudourindine;Pseudouricdine
CBNumber: CB7125832
Molecular Formula: C9H12N2O6
Formula Weight: 244.2
MOL File: 1445-07-4.mol

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Pseudouridine Property

Melting point:: 222 °C
Density: 1.641±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated)
pka: 8.52±0.10(Predicted)
form: Solid
color: White to Off-White
PH: ～9.0
λmax: 264nm(MeOH)(lit.)
InChI: InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3
InChIKey: PTJWIQPHWPFNBW-IZFRNLNUNA-N
SMILES: O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r|

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Safety

HS Code: 2934.99.9001

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2396
Product name: Pseudouridine
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $393
Updated: 2024/03/01

Cayman Chemical

Product number: 23383
Product name: β-Pseudouridine
Purity: ≥95%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 23383
Product name: β-Pseudouridine
Purity: ≥95%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 23383
Product name: β-Pseudouridine
Purity: ≥95%
Packaging: 25mg
Price: $385
Updated: 2024/03/01

TRC

Product number: P839605
Product name: β-Pseudouridine
Packaging: 2.5mg
Price: $55
Updated: 2021/12/16

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Pseudouridine Chemical Properties,Usage,Production

Description

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.

Uses

An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.

Definition

ChEBI: Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite.

Origin

Pseudouridine (Ψ) was the first modified ribonucleotide discovered 7 decades ago, and it has been found in tRNA, rRNA, snRNA, mRNA, and other types of RNA[2].

Biochem/physiol Actions

Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation. Pseudouridine in snRNA has been shown to enhance spliceosomal RNA-pre-mRNA interaction to facilitate splicing regulation[1].

target

Human Endogenous Metabolite

Structure and conformation

Pseudouridine, being one of them, is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine. The C-C bond gives it more rotational freedom and conformational flexibility.In addition, pseudouridine has an extra hydrogen bond donor at the N1 position.

References

[1] Mingjia Chen, Claus-Peter Witte. “A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation.” Plant Cell 32 3 (2020): 722–739.
[2] Pedro Morais,  Yi-Tao Yu,  Hironori Adachi. “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.” Frontiers in Cell and Developmental Biology (2021): 789427.

Pseudouridine Preparation Products And Raw materials

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Preparation Products

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Pseudouridine Suppliers

Canada 2 CHINA 247 China Hong Kong 1 Germany 1 India 2 Japan 1 United Kingdom 4 United States 17 Global 275

BOC Sciences

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View Lastest Price from Pseudouridine manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Pseudouridine 1445-07-4
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-20

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Pseudouridine 1445-07-4
Price: US $999.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pseudouridine 1445-07-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-08-30

1445-07-4, PseudouridineRelated Search:

6-Hydroxypurine Urapidil Impurity 20 ZEBULARINE Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine URAPIDIL 5-METHYL- 6-[(3-chloropropyl)amino]-1,3-dimethyluracil 2-Demethoxy-4-methoxy urapidil 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2,4(1H,3H)-Pyrimidinedione, 1-α-L-arabinofuranosyl- 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-arabinofuranosyl- Uracil Uridine 1,3-DIMETHYLPSEUDOURIDINE 1-methylpseudouridine Pseudouridine PSEUDOURIDINE CEP PSEUDOURIDINE-5'-TRIPHOSPHATE LITHIUM SALT

PSEUDOURIDINE

5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione

5-β-D-ribofuranosyluracil

BETA-PSEUDOURIDINE

B-Pseudouridine

5-β-D-Ribofuranosyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

5-β-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione

Pseudouridine C

5-Ribosyluracil

NSC 162405

β-D-Pseudouridine

2,4(1H,3H)-PyriMidinedione, 5-b-D-ribofuranosyl-

5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

y-Uridine

2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-

Uridine Impurity 20（β-Pseudouridine）

β-Pseudouridine

Pseudourindine

Pseudo-UTP

Pseudoruidine

Pseudouridine, Beta-Pseudouridine, ψ

Pseudouridine, natural antibiotics, RNA modified nucleosides

Pseudouricdine

2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-

Uridine Impurity 2 (Pseudouridine)

1445-07-4

445-07-4

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleotides

Pharmaceutical

Nucleosides