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ailanthone

Product Name
ailanthone
CAS No.
981-15-7
Chemical Name
ailanthone
Synonyms
ailanthone;Δ13-Dehydrochaparrinone;13,21-Didehydrochaparrinone;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH);(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...;11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-;(1R,2R,3aS,3a1S,6aR,7aS,11S,11aS,11bR)-1,2,11-Trihydroxy-8,11a-dimethyl-3-methylene-2,3,3a,4,7,7a,11,11a-octahydro-1H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione
CBNumber
CB71327541
Molecular Formula
C20H24O7
Formula Weight
376.4
MOL File
981-15-7.mol
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ailanthone Property

Melting point:
235-237 °C
Boiling point:
641.0±55.0 °C(Predicted)
Density 
1.47
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM)
form 
A crystalline solid
pka
11.85±0.70(Predicted)
color 
White to off-white
LogP
-0.760 (est)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2143
Product name
Ailanthone
Purity
≥98% (HPLC)
Packaging
5MG
Price
$143
Updated
2023/06/20
Sigma-Aldrich
Product number
SML2143
Product name
Ailanthone
Purity
≥98% (HPLC)
Packaging
25MG
Price
$567
Updated
2023/06/20
Cayman Chemical
Product number
29194
Product name
Ailanthone
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29194
Product name
Ailanthone
Packaging
25mg
Price
$485
Updated
2024/03/01
Cayman Chemical
Product number
29194
Product name
Ailanthone
Packaging
1mg
Price
$37
Updated
2024/03/01
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ailanthone Chemical Properties,Usage,Production

Description

Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.

Uses

Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.

Definition

ChEBI: Ailanthone is a triterpenoid.

ailanthone Preparation Products And Raw materials

Raw materials

Preparation Products

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ailanthone Suppliers

China 127 France 1 United Kingdom 1 United States 11 Global 140
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
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65
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
Wilshire Chemical Company Inc.
Tel
--
Fax
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Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
NE Scientific
Tel
--
Fax
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Country
United States
ProdList
5030
Advantage
55
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
FortopChem Technology Limited
Tel
--
Fax
--
Email
sales@fortopchem.com
Country
United States
ProdList
1099
Advantage
50
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View Lastest Price from ailanthone manufacturers

Career Henan Chemical Co
Product
ailanthone 981-15-7
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-10

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  • 11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione
  • 13,21-Didehydrochaparrinone
  • ailanthone
  • Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-
  • (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
  • Δ13-Dehydrochaparrinone
  • Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-
  • (1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...
  • 2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH)
  • (1R,2R,3aS,3a1S,6aR,7aS,11S,11aS,11bR)-1,2,11-Trihydroxy-8,11a-dimethyl-3-methylene-2,3,3a,4,7,7a,11,11a-octahydro-1H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione
  • 981-15-7
  • Diterpenoids